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Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263) antibody

Details for Product No. ABIN123328
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Antigen
Epitope
AA 249-263
(13), (6), (6), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(106), (2), (1)
Host
Rabbit
(76), (27), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(66), (43), (40), (15), (14), (8), (7), (5), (4), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123328
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Immunogen Synthetic peptide corresponding to amino acids 249 to 263 of human DcR2 precursor (2)
Purification Protein G chromatography
Alternative Name CD264 / TRAILR4
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL/R4, or TRUNDD (2). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. Alternate Names: TRAIL-R4, CD264.
UniProt Q9UBN6
Research Area Signaling, Apoptosis/Necrosis
Application Notes Western blot: 1:1000 to 1:2000 dilution. Recommended Positive Control: HeLa (a band of approximate molecular weight 35 kD will be detected). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263) antibody Western blot analysis of 50 ug of whole cell lysate from HeLa cells with anti-DcR2 at 1:1000 dilution
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) (AA 249-263) antibody (2) Immunohistochemical staining of HeLa cells using anti-DcR2 (ID) at 10 µg/ml.
General Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).

Marsters, Sheridan, Pitti et al.: "A novel receptor for Apo2L/TRAIL contains a truncated death domain." in: Current biology : CB, Vol. 7, Issue 12, pp. 1003-6, 1998 (PubMed).

Mitsiades, Poulaki, Tseleni-Balafouta et al.: "Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand." in: Cancer research, Vol. 60, Issue 15, pp. 4122-9, 2000 (PubMed).

Validation Images
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