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Deoxyribonuclease II, Lysosomal (DNASE2) (AA 347-360) antibody

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AA 347-360
(8), (7), (6), (3), (1), (1), (1), (1)
(49), (19), (17)
(47), (4)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(38), (13), (12), (12), (6), (4), (3), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Peptide corresponding to amino acids 347 to 360 of human DNase precursor
Purification Protein G chromatography
Alternative Name Deoxyribonuclease-2-alpha (DNASE2 Antibody Abstract)
Background DNase II causes chromatin condensation and DNA fragmentation. The DNase II gene encodes for a proenzyme of approximate molecular mass of 40 kDa. The active enzyme consists of a heterodimer of 32 kDa and 12 kDa.
UniProt O00115
Application Notes Western blot: 2 - 4 ug/ml. Recommended Positive Control: human spleen. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Deoxyribonuclease II, Lysosomal (DNASE2) (AA 347-360) antibody (ABIN123330) Western blot analysis of 50 ug of total cell lysate from HeLa cells with anti-DFF (CT...
General Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Wyllie: "Apoptosis. An endonuclease at last." in: Nature, Vol. 391, Issue 6662, pp. 20-1, 1998 (PubMed).

Liu, Zou, Slaughter et al.: "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis." in: Cell, Vol. 89, Issue 2, pp. 175-84, 1997 (PubMed).

Catalog No. ABIN123330

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