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Details for Product No. ABIN123338

Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (AA 371-655) antibody

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Antigen
Synonyms BM-018, CD358, DR6, TR7, R74815, AA959878, TNFRSF21, dr6, im:6795346, wu:fa55e01, wu:fb02e11, wu:fc29a09, wu:fi27h08, tnfrsf21, MGC146356
Epitope
»Alternatives AA 371-655
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN123338
Quantity 0.1 mg
Price
313.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Cytoplasmic domain (amino acids 371-655) of human DR6 protein
Purification Protein G chromatography
Alternative Name TNFRSF21 / Death receptor 6 (DR6)
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6) (1). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are related to those of osteoprotegerin (OPG) (2) and TNFR2 (3) with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%) (1).
UniProt O75509
Application Notes Western blot: 2 - 4 ug/ml. Recommended positive control: Daudi, HeLa, or Jurkat. A ~66 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Simonet, Lacey, Dunstan et al.: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density." in: Cell, Vol. 89, Issue 2, pp. 309-19, 1997 (PubMed).

Pan, Bauer, Haridas et al.: "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor." in: FEBS letters, Vol. 431, Issue 3, pp. 351-6, 1998 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)", type "Antibodies"
Hosts (67), (30), (7)
Reactivities (94), (22), (20), (17), (17), (16), (1), (1)
Applications (56), (44), (23), (20), (14), (9), (7), (6), (4), (4), (3), (1)
Conjugates (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (10), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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