Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (AA 371-655) antibody

Details for Product No. ABIN123338
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Epitope
AA 371-655
(23), (12), (8), (7), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(101), (28), (22), (17), (17), (16), (4)
Host
Rabbit
(82), (28), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(63), (36), (28), (18), (13), (11), (7), (7), (5), (4), (3)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN123338
324.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Cytoplasmic domain (amino acids 371-655) of human DR6 protein
Purification Protein G chromatography
Alternative Name TNFRSF21 / Death receptor 6 (DR6)
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6) (1). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are related to those of osteoprotegerin (OPG) (2) and TNFR2 (3) with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%) (1).
UniProt O75509
Application Notes Western blot: 2 - 4 ug/ml. Recommended positive control: Daudi, HeLa, or Jurkat. A ~66 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (AA 371-655) antibody Western blot analysis of 30 ug of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells with ABIN123338 at 2 ug/ml.
General Simonet, Lacey, Dunstan et al.: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. ..." in: Cell, Vol. 89, Issue 2, pp. 309-19, 1997 (PubMed).

Pan, Bauer, Haridas et al.: "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor." in: FEBS letters, Vol. 431, Issue 3, pp. 351-6, 1998 (PubMed).

Validation Images
Did you look for something else?
back to top