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Details for Product No. ABIN123339

serine/threonine Kinase 17a (STK17A) (AA 5-19) antibody

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Antigen
Synonyms DRAK1, RDRAK1, im:6905684, LOC100226911, STK17A
Epitope
»Alternatives AA 5-19
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN123339
Quantity 0.1 mg
Price
654.50 $   Plus shipping costs $45.00
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Immunogen Peptide corresponding to amino acids 5 to 19 of human DRAK1 protein
Purification Protein G Chromatography
Alternative Name STK17A / DRAK1
Background Protein kinases play important roles in the signal transduction in response to a variety of external stimuli. Recently, several protein kinases have been identified that may also be involved in apoptotic process. Overexpression of a serine/threonine kinase, ZIP kinase can cause the morphological changes typical of apoptosis in NIH 3T3 cells (1). Sanjo et al, have identified two new protein kinases DRAK1 and DRAK2 (Death Receptor Associated Kinase 1 and 2) (1). Both DRAKs and ZIP kinase share significant homology at the amino acid level (1,2). The kinase domains of both DRAKs, ZIP kinase are homologous to DAP (Death-associated protein) kinase, which is involved in the apoptotic signaling induced by interferon-g. Overexpression of DRAKs in NIH 3T3 cells lead to apoptosis. These transfection experiments suggest that C- terminal domain of DRAKs are important for induction of apoptosis.
UniProt Q9UEE5
Application Notes Western blot: 2 - 4 ug/ml. Recommended positive control: HeLa. A ~66 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).

Alternatives for antigen "serine/threonine Kinase 17a (STK17A)", type "Antibodies"
Hosts (50), (12), (3)
Reactivities (65), (19), (13), (2), (1), (1), (1), (1), (1)
Applications (52), (23), (10), (9), (8), (3), (3), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (6), (4), (4), (3), (2), (1), (1)
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