Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 369-382) antibody

Details for Product No. ABIN123346
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Antigen
Synonyms AU042498
Epitope
AA 369-382
(5), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(18), (4), (4)
Host
Rabbit
(10), (8)
Clonality
Polyclonal
Application
Western Blotting (WB)
(13), (8), (3), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN123346
Quantity 0.1 mg
Price
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Immunogen Peptide corresponding to amino acids 369 to 382 of human GFRa-1
Purification Protein G chromatography
Alternative Name GFRA1 / GDNFR-alpha
Background Glial cell derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of glycosyl phosphadidylinositol linked protein GDNFRa, also known as GFRa-1 which is a cell surface receptor for GDNF. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1). GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Alternate Names: GDNFRa / RETL1 / TrnR1.
UniProt P56159
Application Notes Western blot: 2.0 - 4.0 ug/ml. Recommended positive control: human brain membrane. In human brain membrane, a 55 kDa band should be observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 369-382) antibody Western blot analysis for GFRa-1 using ABIN123346 at 2 ug/ml dilution against 20 ug/lane of lysates of crude membrane fractions of human brain (lane 1), liver (lane 2), kidney (lane 3), and spleen (lane 4), respectively.
General Treanor, Goodman, de Sauvage et al.: "Characterization of a multicomponent receptor for GDNF." in: Nature, Vol. 382, Issue 6586, pp. 80-3, 1996 (PubMed).

Jing, Wen, Yu et al.: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Hosts (10), (8)
Reactivities (18), (4), (4)
Applications (13), (8), (3), (1), (1), (1), (1)
Epitopes (5), (2), (2), (1), (1), (1), (1)
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