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Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 369-382) antibody

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AA 369-382
(2), (2), (2), (2), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(13), (5), (5)
(11), (2)
Western Blotting (WB)
(12), (4), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Peptide corresponding to amino acids 369 to 382 of human GFRa-1
Purification Protein G chromatography
Alternative Name GFRA1 / GDNFR-alpha (GFRA1 Antibody Abstract)
Background Glial cell derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of glycosyl phosphadidylinositol linked protein GDNFRa, also known as GFRa-1 which is a cell surface receptor for GDNF. GDNFRa was also termed Ret ligand 1 (RETL1) or TGF-b-related neurotrophic factor receptor 1 (TrnR1). GFRa-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Alternate Names: GDNFRa / RETL1 / TrnR1.
UniProt P56159
Application Notes Western blot: 2.0 - 4.0 ug/ml. Recommended positive control: human brain membrane. In human brain membrane, a 55 kDa band should be observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 369-382) antibody (ABIN123346) Western blot analysis for GFRa-1 using ABIN123346 at 2 ug/ml dilution against 20 ug/l...
General Jing, Wen, Yu et al.: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Treanor, Goodman, de Sauvage et al.: "Characterization of a multicomponent receptor for GDNF." in: Nature, Vol. 382, Issue 6586, pp. 80-3, 1996 (PubMed).

Catalog No. ABIN123346

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