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Details for Product No. ABIN123352

Histone Deacetylase 4 (HDAC4) (AA 194-209) antibody

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Antigen
Synonyms
AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, AI047285, 4932408F19Rik, wu:fa96d08, wu:fc56f08, zgc:152701, CG1770, DHDAC4, Dmel\\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, dana_GLEANR_19 ... show more
Epitope
»Alternatives AA 194-209
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN123352
Quantity 0.1 mg
Price
489.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 194-209 of human HDAC4
Purification Purified
Alternative Name HDAC4
Background Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
UniProt P56524
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blot: 0.5 - 2.0 ug/ml. ChIP:Refer to Caretti et al (2003, Fig.3) and Imbriano (2005, Fig 7) for details. Immunoprecipitation. Recommended positive control: Jurkat or NIH 3T3. A 140 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05 % BSA and 0.05% sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).

Meinke, Liberator: "Histone deacetylase: a target for antiproliferative and antiprotozoal agents." in: Current medicinal chemistry, Vol. 8, Issue 2, pp. 211-35, 2001 (PubMed).

Alternatives for antigen "Histone Deacetylase 4 (HDAC4)", type "Antibodies"
Hosts (156), (19), (1)
Reactivities (167), (101), (75), (35), (24), (24), (1), (1), (1), (1)
Applications (147), (43), (32), (30), (26), (23), (16), (7), (6), (2), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (34), (21), (14), (8), (6), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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