Histone Deacetylase 6 (HDAC6) (AA 1-16), (N-Term) antibody

Details for Product No. ABIN123354
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Antigen
Epitope
AA 1-16, N-Term
(21), (16), (16), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(128), (60), (27), (13), (5), (3)
Host
Rabbit
(117), (17), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Western Blotting (WB)
(110), (61), (53), (36), (28), (20), (15), (12), (7), (6), (6), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123354
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Immunogen Peptide corresponding to amino acids 1-16 of human HDAC6
Purification Protein G Chromatography.
Alternative Name HDAC6
Background Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
UniProt Q9UBN7
Research Area Chromatin and Nuclear Signaling, Wnt, DNA/RNA, Transcription Factors
Application Notes Western blot: 2.0 ug/ml. Immunoprecipitation. ChIP. Recommended positive control: NIH 3T3. In NIH 3T3, a 134 kDa band is observed. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% Sodium Azide as preservative and 0.05% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Histone Deacetylase 6 (HDAC6) (AA 1-16), (N-Term) antibody Western blot analysis of HDAC6 in NIH-3T3 cell lysate with ABIN123354.
General Cress, Seto: "Histone deacetylases, transcriptional control, and cancer." in: Journal of cellular physiology, Vol. 184, Issue 1, pp. 1-16, 2000 (PubMed).

Meinke, Liberator: "Histone deacetylase: a target for antiproliferative and antiprotozoal agents." in: Current medicinal chemistry, Vol. 8, Issue 2, pp. 211-35, 2001 (PubMed).

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