Interleukin 17 Receptor B (IL17RB) (AA 102-118) antibody

Details for Product No. ABIN123362
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Antigen
Epitope
AA 102-118
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(32), (22), (20), (17), (17), (17)
Host
Rabbit
(32), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(21), (14), (8), (8), (5), (4), (2), (2), (2)
Pubmed 5 references available
Quantity 0.2 mL
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Catalog No. ABIN123362
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Immunogen Amino acids 102-118 of human IL-17BR protein AA Sequence:CNYTEAFQTQTRPSGGK
Purification Protein G Chromatography.
Alternative Name IL17RB / IL17BR
Background Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are IL-17B, IL-17C, and IL-17E. Like IL-17, IL-17B, C, and E are able to induce proinflammatory responses but don't bind to the IL-17 receptor suggesting additional IL-17R related receptors might exist. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in kidney and liver and at moderate level in small intestine, colon, and brain.
UniProt Q9NRM6
Application Notes Western blot: 1/500 - 1/1000. Recommended positive control: HeLa. In HeLa, a 45 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative and 0.1 mg/ml BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Interleukin 17 Receptor B (IL17RB) (AA 102-118) antibody Western blot analysis of IL-17BR in HeLa cell lysate using ABIN123362 at a 1:500 dilution
General Shalom-Barak, Quach, Lotz: "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB." in: The Journal of biological chemistry, Vol. 273, Issue 42, pp. 27467-73, 1998 (PubMed).

Matusevicius, Kivisaekk, He et al.: "Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 5, Issue 2, pp. 101-4, 1999 (PubMed).

Tartour, Fossiez, Joyeux et al.: "Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice." in: Cancer research, Vol. 59, Issue 15, pp. 3698-704, 1999 (PubMed).

Shi, Ullrich, Zhang et al.: "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 19167-76, 2000 (PubMed).

Lee, Ho, Maruoka et al.: "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." in: The Journal of biological chemistry, Vol. 276, Issue 2, pp. 1660-4, 2001 (PubMed).

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