Interleukin 17 Receptor B (IL17RB) antibody

Antigen: Interleukin 17 Receptor B (IL17RB)

Synonyms: CRL4, EVI27, IL17BR, IL17RH1, MGC5245, Evi27, Il17br, IL-17ER, IL-17Rh1, IL17RB, MGC148783

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN123362

Additional Information

Alternative name: IL17RB / IL17BR

UniProt: Q9NRM6

Immunogen: Amino acids 102-118 of human IL-17BR protein AA Sequence:CNYTEAFQTQTRPSGGK

Cross-Reactivity: Human

Description: Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are IL-17B, IL-17C, and IL-17E. Like IL-17, IL-17B, C, and E are able to induce proinflammatory responses but don't bind to the IL-17 receptor suggesting additional IL-17R related receptors might exist. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in kidney and liver and at moderate level in small intestine, colon, and brain.

Specificity: This antibody is specific for IL-17BR. Genebank Info (Protein): AAF78776

Application Details

Application Notes: Western blot: 1/500 - 1/1000. Recommended positive control: HeLa. In HeLa, a 45 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: PBS containing 0.02 % sodium azide and 0.1 mg/ml BSA

Storage: Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.

Restrictions: For Research Use only

Images

Western blot analysis of IL-17BR in HeLa cell lysate using ABIN123362 at a 1:500 dilution

Publications

Shalom-Barak, Quach, Lotz: "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB." in: The Journal of biological chemistry, Vol. 273, Issue 42, pp. 27467-73, 1998 (PubMed).

Matusevicius, Kivisaekk, He et al.: "Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis." in: Multiple sclerosis (Houndmills, Basingstoke, England), Vol. 5, Issue 2, pp. 101-4, 1999 (PubMed).

Tartour, Fossiez, Joyeux et al.: "Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice." in: Cancer research, Vol. 59, Issue 15, pp. 3698-704, 1999 (PubMed).

Shi, Ullrich, Zhang et al.: "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 19167-76, 2000 (PubMed).

Lee, Ho, Maruoka et al.: "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." in: The Journal of biological chemistry, Vol. 276, Issue 2, pp. 1660-4, 2001 (PubMed).