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Suppressor of Cytokine Signaling 5 (SOCS5) antibody

Details for Product No. ABIN123365
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Antigen
Reactivity
Human, Mouse (Murine)
(34), (14), (14)
Host
Rabbit
(24), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(21), (11), (10), (8), (4), (2), (2)
Pubmed 2 references available
Quantity 0.2 mL
Shipping to United States (Change)
Availability Discontinued
Catalog No. ABIN123365
456.50 $
Plus shipping costs $45.00
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide containing amino acid residues of human SOCS5 protein
Purification Protein G Chromatography.
Alternative Name SOCS5 / CIS6
Background The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each member of the family has been determined by gene knockout experiments (1). SOCS5 protein is preferentially expressed in committed T-helper (Th1) cells. The action of SOCS5 is probably mediated by its interaction with the cytoplasmic domain of IL-4 receptor. During Th1 differentiation, there is a reduction in the association of Janus kinase 1 with the IL-4 receptor (IL-4R), which is correlated with the expression of SOCS5.pressor of cytokine signaling-5 (SOCS5). It has been also shown that in the overexpression of SOCS5 in transgenic mice leads to impaired Th2 development, suggesting that SOCS5 may plan an important role in the Th1 differentiation by regulating a balance between Th1 and Th2 (2).
UniProt O75159
Application Notes Western blot: 1:500 dilution. Use human or mouse spleen lysate for positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative and 0.1 mg/ml BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Suppressor of Cytokine Signaling 5 (SOCS5) antibody Western blot analysis for SOCS5 using ABIN123365 at 1:500 dilution against 15 ug/lane of mouse spleen (lane A) and human spleen (lane B) lysates.
General Krebs, Hilton: "SOCS proteins: negative regulators of cytokine signaling." in: Stem cells (Dayton, Ohio), Vol. 19, Issue 5, pp. 378-87, 2001 (PubMed).

Seki, Hayashi, Matsumoto et al.: "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 13003-8, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN123365
456.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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