SET Nuclear Oncogene (SET) (AA 135-151), (AA 66-81) antibody

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Antigen
Alternatives
Epitope
AA 66-81, AA 135-151
(2), (2), (1), (1)
Reactivity
Human
(13), (3), (2)
Host
Rabbit
(10), (3)
Clonality
Polyclonal
Application
Western Blotting (WB)
(10), (3), (2), (2), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Synthetic peptides of amino acids 66-81 and 135-151 of human INHAT-1Remarks: Sequence homology is 100% in mouse and rat.
Characteristics Synonyms: I-2PP2A, TAF-I, PHAPII, IGAAD, Phosphatase 2A inhibitor I2PP2A, Template-activating factorI, Inhibitor of granzyme A-activated DNase
Purification Protein G Chromatography
Alternative Name SET / I2PP2A (SET Antibody Abstract)
Background INHAT (inhibitor of acetyltransferases) complex binds to histones and masks them frombeing substrate for acetyltransferase. Endogenous INHAT subunits, which include theSet/TAF-Ibeta oncoprotein, associate with chromatin in vivo and can block coactivatormediated transcription when transfected in cells.
Gene ID 6418
UniProt Q01105
Pathways Apoptosis
Application Notes Western blot: 1.0 - 2.0 ug/ml. Recommended positive control: Jurkat. An ~37 kDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide and 0.1 mg/ml BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-SET Nuclear Oncogene (SET) (AA 135-151), (AA 66-81) antibody (ABIN123368) Western blot analysis of INHAT-1 using ABIN123368 against Jurkat cell lysate.
General Seo, Macfarlan, McNamara et al.: "Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 14005-10, 2002 (PubMed).