Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 38-54), (AA 120-136) antibody

Details for Product No. ABIN123372
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AA 38-54, AA 120-136
(44), (37), (15), (14), (13), (12), (12), (5), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(147), (34), (13), (6), (1)
(107), (29), (22)
(9), (7), (7), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Immunoprecipitation (IP), Western Blotting (WB)
(125), (64), (24), (20), (10), (10), (7), (7), (6), (5), (5), (3), (3), (3), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN123372
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Immunogen Mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4
Isotype IgG
Purification Protein G Chromatography
Alternative Name IRAK4
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members (2). The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified (3). IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges (4, 5).
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation
Application Notes Western blot (1:500-1:1000, Positive control: NIH 3T3). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 38-54), (AA 120-136) antibody Western blot analysis of IRAK-4 in 30 ugs of NIH 3T3 cell lysate using ABIN123372 at 1:500 dilution.
General Shirai, Koizumi, Ogawa et al.: "[Anti-signal recognition particle (SRP) antibody positive polymyositis refractory to corticosteroid treatment]" in: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, Vol. 96, Issue 11, pp. 2522-4, 2007 (PubMed).

Lai, Chen, Fen et al.: "[Genetic polymorphism of fifteen short tandem repeat loci in Chinese Drungs]" in: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Vol. 19, Issue 6, pp. 502-4, 2002 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Cao, Xiong, Takeuchi et al.: "TRAF6 is a signal transducer for interleukin-1." in: Nature, Vol. 383, Issue 6599, pp. 443-6, 1996 (PubMed).

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