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Details for Product No. ABIN123379

Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer156), (pSer152) antibody

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Antigen
Synonyms 80K-L, MACS, PKCSL, PRKCSL, Macs, KINC, macs, marcks, wu:fb55c06, wu:fb92d04, wu:fc19b04, wu:fc44a10, zgc:110235, MGC89127, MARCKS
Epitope
»Alternatives pSer156, pSer152
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN123379
Quantity 0.1 mL
Price
599.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho- Ser152 and phospho-Ser156 of rat MARCKS
Purification Sequential chromatography on phospho- and non-phosphopeptide affinity columns
Alternative Name MARCKS
Background Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation. Moreover, MARCKS is a member of a family of calmodulin binding proteins. Phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin.
UniProt P29966
Research Area Cardiovascular
Application Notes Western blot: 1:1000. Recommended Positive Control: rat brain (an ~87 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% glycerol
Storage -20 °C
Storage Comment For long term storage -80°C is recommended, but shorter term storage at -20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Shelf Life: one year from despatch.
Expiry Date 12 months
Thelen, Rosen, Nairn et al.: "Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane." in: Nature, Vol. 351, Issue 6324, pp. 320-2, 1991 (PubMed).

Spizz, Blackshear: "Protein kinase C-mediated phosphorylation of the myristoylated alanine-rich C-kinase substrate protects it from specific proteolytic cleavage." in: The Journal of biological chemistry, Vol. 271, Issue 1, pp. 553-62, 1996 (PubMed).

Alternatives for antigen "Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS)", type "Antibodies"
Hosts (188), (10), (2)
Reactivities (176), (133), (124), (53), (40), (36), (24), (3), (3), (1), (1), (1)
Applications (139), (54), (48), (40), (30), (21), (16), (5), (4), (2), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (27), (25), (23), (22), (21), (9), (7), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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