MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody

Details for Product No. ABIN123393
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN123393
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Immunogen Synthetic peptide of human MRE11
Purification Protein G Chromatography
Alternative Name MRE11
Background MRE11 in yeast belongs to RAD50 epistasis group gene, MRE11, blocks meiotic recombination and play roles in non-homologous end-joining (NHEJ) DNA double-strand break (DSB) repair pathways. Human MRE11 shares approximately 50% identity at the amino acid level with its yeast counterpart in the N-terminal half of the protein (1). Repair of DNA double-strand breaks by radiation is dependent on a multifunctional complex containing Rad50, MRE11, and the NBS1 gene product, p95 (NBS protein, nibrin) (2). In addition function of MRE11 is also linked to ataxia telangiectasia mutated (ATM) protein kinase (3), TTAGGG repeat binding factor2 (TRF2) (4), and Ku70 (5). A mutation of the hMRE11 gene may be important in a new ataxia telangiectasia-like disorder (ATLD) (6). MRE11 is expressed at the highest levels in proliferating tissues.
UniProt P49959
Application Notes Western blot (1-2 ug/ml). Recommended Positive Control: 293. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS and 0.02 % (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) antibody Western blot analysis for Mre11 in 293 cells: 10 microgram per lane 293 cell lysate was resolved by SDS-PAGE and the blot was probed with 2 ug/ml anti-Mre11 antibody (Cat. # ABIN123393).
General Li, Zhu, Waterton et al.: "Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors." in: Journal of magnetic resonance imaging : JMRI, Vol. 12, Issue 2, pp. 347-57, 2000 (PubMed).

Petrini: "The Mre11 complex and ATM: collaborating to navigate S phase." in: Current opinion in cell biology, Vol. 12, Issue 3, pp. 293-6, 2000 (PubMed).

Dong, Zhong, Chen: "The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19513-6, 1999 (PubMed).

Petrini, Walsh, DiMare et al.: "Isolation and characterization of the human MRE11 homologue." in: Genomics, Vol. 29, Issue 1, pp. 80-6, 1996 (PubMed).

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