Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 233-248) antibody

Details for Product No. ABIN123399
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Antigen
Epitope
AA 233-248
(17), (16), (14), (9), (7), (6), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(139), (65), (40), (4), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(120), (27), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(134), (53), (41), (24), (13), (11), (10), (8), (5), (4), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN123399
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Immunogen Peptide corresponding to amino acid residues 233-248 of human MyD88
Purification Protein G Chromatography
Alternative Name MYD88
Background MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.
UniProt Q99836
Application Notes Western blot: 0.5 - 2.0 ug/ml. Recommended positive control: human spleen or RAW. A 32 KDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 233-248) antibody Western blot analysis of MyD88 in human spleen cell lysate using 0.5 ug/ml of ABIN123399.
General Hardiman, Rock, Balasubramanian et al.: "Molecular characterization and modular analysis of human MyD88." in: Oncogene, Vol. 13, Issue 11, pp. 2467-75, 1997 (PubMed).

Bonnert, Garka, Parnet et al.: "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family." in: FEBS letters, Vol. 402, Issue 1, pp. 81-4, 1997 (PubMed).

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