Myeloid Differentiation Primary Response Gene (88) (MYD88) antibody

Antigen: Myeloid Differentiation Primary Response Gene (88) (MYD88)

Synonyms: MYD88D, XMyD88, myd88d, MGC84928, DMMYD88, EP(2)2535, Kra, LD20892, MYD88, dMyD88, DmelCG2078, CG2078, zgc:103541, GB12344, NV10640, myd88, IRAK-2, MGC150550, AI649099, MGC102586, 6330415L08Rik, irak-2, MGC79591, IRAK2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN123399

Additional Information

Alternative name: MYD88

UniProt: Q99836

Immunogen: Peptide corresponding to amino acid residues 233-248 of human MyD88

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Description: MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.

Synonyms: MYD88D, XMyD88, myd88d, MGC84928, DMMYD88, EP(2)2535, Kra, LD20892, MYD88, dMyD88, DmelCG2078, CG2078, zgc:103541, GB12344, NV10640, myd88, IRAK-2, MGC150550, AI649099, MGC102586, 6330415L08Rik, irak-2, MGC79591, IRAK2

Application Details

Application Notes: Western blot: 0.5 - 2.0 ug/ml. Recommended positive control: human spleen or RAW. A 32 KDa band is observed. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: PBS containing 0.05% BSA and 0.05% sodium azide

Storage: Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.

Restrictions: For Research Use only

Images

Western blot analysis of MyD88 in human spleen cell lysate using 0.5 ug/ml of ABIN123399.

Publications

Hardiman, Rock, Balasubramanian et al.: "Molecular characterization and modular analysis of human MyD88." in: Oncogene, Vol. 13, Issue 11, pp. 2467-75, 1997 (PubMed).

Bonnert, Garka, Parnet et al.: "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family." in: FEBS letters, Vol. 402, Issue 1, pp. 81-4, 1997 (PubMed).