GATA Zinc Finger Domain Containing 2A (GATAD2A) (AA 137-150) antibody

Details for Product No. ABIN123409
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Antigen
Epitope
AA 137-150
(18), (8), (6), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(32), (10), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(25), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(35), (18), (4), (4), (3), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.2 mL
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Catalog No. ABIN123409
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Immunogen Synthetic peptide corresponding to aa 137-150 of mouse p66a
Characteristics Synonyms: GATA zinc finger domain-containing protein 2A, Transcriptional repressor p66-alpha
Purification Serum
Alternative Name GATAD2A / Hp66 alpha
Background Methylation of cytosine at CpG dinucleotides is a common feature of many highereukaryotic genomes (1-3). Increasing evidence indicates that recruitement of histonedeacetylase complexes by methyl-CpG-binding proteins (MeCP) is a major mechanism ofmethylated DNA silencing. P66, a zinc finger-containing protein is one of the componentsof the MeCP1 complex (4). P66 and p68, the two components of MeCP1 are different formsof the same zinc finger-containing protein and are conserved from C. elegans to humans. Homologs of p66 from different organisms revealed two highly conserved regions, CR1 andCR2. While CR1 is involved in the association of p66 with other MeCP1 components, CR2plays an important role in targeting p66 and MBD3 to specific loci (4).
Gene ID 100047029
UniProt Q8CHY6
Application Notes Western blot: 1: 500-1: 1000. Recommended Positive Control: HeLa or RAW. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-GATA Zinc Finger Domain Containing 2A (GATAD2A) (AA 137-150) antibody Western blot analysis of p66a in 15 ugs of HeLa cell lysate using IMG-509 at 1:500 dilution.
General Tong, Hassig, Schnitzler et al.: "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex." in: Nature, Vol. 395, Issue 6705, pp. 917-21, 1998 (PubMed).

Xue, Wong, Moreno et al.: "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities." in: Molecular cell, Vol. 2, Issue 6, pp. 851-61, 1999 (PubMed).

Zhang, Ng, Erdjument-Bromage et al.: "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation." in: Genes & development, Vol. 13, Issue 15, pp. 1924-35, 1999 (PubMed).

Feng, Cao, Xia et al.: "Identification and functional characterization of the p66/p68 components of the MeCP1 complex." in: Molecular and cellular biology, Vol. 22, Issue 2, pp. 536-46, 2001 (PubMed).

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