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Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 44-60), (AA 187-198) antibody

Details for Product No. ABIN123411
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Antigen
Epitope
AA 44-60, AA 187-198
(12), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(41), (25), (24), (2), (2), (1)
Host
Rabbit
(39), (2)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(41), (29), (22), (8), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123411
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Immunogen Mixture of synthetic peptides corresponding to amino acids 44-60 and 187-198 of human PIASg
Purification Protein G Chromatography
Alternative Name PIAS3
Background The interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. The signal transducers and activators of transcription (STAT) proteins play important roles in the activation of these pathways. Recently, a family of proteins has been identified that inhibits activated STATS and are named as Protein Inhibitors of Activated STAT (PIAS). PIAS proteins comprise a family of five mammalian proteins, which have been identified as potentially important down regulators of the STAT-signaling pathway. The cDNA for mouse and human PIASg encodes a protein of 507 amino acids that is highly homologous to the human protein and is expressed in the mouse as early as d 7.5 of gestation. In situ hybridizations of staged mouse embryos localized the transcript for the PIASgamma gene to the limbs, neuroepithelium, and the inner root sheath of the hair follicle, suggesting a role in the development of these structures. This protein is also present in hair follicle of human scalp hair and in monkey neuronal cells. Thus PIASg exhibits a highly selective pattern of expression, suggesting that it modulates the response of cells to developmental cues.
UniProt Q9Y6X2
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Immunoflourescence (see Ihara et al, 2005 for details). Western blot: 1- 2 ug/ml. Recommended Positive Control: Jurkat. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 44-60), (AA 187-198) antibody Western blot analysis of PIASgamma in Jurkat cell lysate using ABIN123411 at 2 ug/ml.
General Uddin, Chamdin, Platanias: "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 24627-30, 1995 (PubMed).

Schindler, Darnell: "Transcriptional responses to polypeptide ligands: the JAK-STAT pathway." in: Annual review of biochemistry, Vol. 64, pp. 621-51, 1995 (PubMed).

Darnell: "STATs and gene regulation." in: Science (New York, N.Y.), Vol. 277, Issue 5332, pp. 1630-5, 1997 (PubMed).

Sturm, Kollerits, Neyer et al.: "Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study." in: Experimental gerontology, 2008 (PubMed).

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