Protein Arginine Methyltransferase 6 (PRMT6) (AA 23-43) antibody

Details for Product No. ABIN123417
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Antigen
Epitope
AA 23-43
(6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(57), (23), (21), (13), (13), (13), (7), (1)
Host
Rabbit
(41), (18), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (19), (12), (10), (9), (6), (6), (6), (3), (1)
Pubmed 2 references available
Quantity 0.2 mL
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Catalog No. ABIN123417
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Immunogen Synthetic peptides corresponding to amino acids 23-43 of human PRMT6. AA Sequence: CEEDGAEREAALERPRRTKRER
Purification Protein G chromatography
Alternative Name PRMT6 / HRMT1L6
Background Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N- methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG- monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activity. GFP- fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. Alternate Names: PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, , Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6.
UniProt Q96LA8
Application Notes Western blot: 1/500 - 1/1000. HeLa cell lysate or RAW can be used as positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, containing 0.05% BSA and 0.05% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 23-43) antibody Western blot analysis of PRMT6 in cell lysates from HeLa cells using ABIN123417 at 1:500 dilution. Twenty microgram of HeLa cell lysate was loaded per well of a mini gel.
General Chen, Ma, Hong et al.: "Regulation of transcription by a protein methyltransferase." in: Science (New York, N.Y.), Vol. 284, Issue 5423, pp. 2174-7, 1999 (PubMed).

Frankel, Yadav, Lee et al.: "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3537-43, 2002 (PubMed).

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