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Details for Product No. ABIN123417

Protein Arginine Methyltransferase 6 (PRMT6) (AA 23-43) antibody

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HRMT1L6, Hrmt1l6, AW124876, BB233495, CG9927, DART6, Dmel\\CG9927, hrmt6, hrmt1l6, im:6908706, PRMT6, ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6, ATPRMT6, protein arginine methyltransfe ... show more
»Alternatives AA 23-43
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN123417
Quantity 0.2 mL
445.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Synthetic peptides corresponding to amino acids 23-43 of human PRMT6. AA Sequence: CEEDGAEREAALERPRRTKRER
Purification Protein G chromatography
Alternative Name PRMT6 / HRMT1L6
Background Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N- methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG- monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activity. GFP- fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. Alternate Names: PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, , Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6.
UniProt Q96LA8
Application Notes Western blot: 1/500 - 1/1000. HeLa cell lysate or RAW can be used as positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, containing 0.05% BSA and 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Chen, Ma, Hong et al.: "Regulation of transcription by a protein methyltransferase." in: Science (New York, N.Y.), Vol. 284, Issue 5423, pp. 2174-7, 1999 (PubMed).

Frankel, Yadav, Lee et al.: "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3537-43, 2002 (PubMed).

Alternatives for antigen "Protein Arginine Methyltransferase 6 (PRMT6)", type "Antibodies"
Hosts (38), (14), (2)
Reactivities (51), (21), (21), (13), (13), (13), (6)
Applications (42), (20), (12), (10), (6), (4), (4), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (1), (1), (1), (1)