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RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 11-30)

Details for Product anti-RIPK2 Antibody No. ABIN123430, Supplier: Login to see New
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AA 11-30
(31), (19), (10), (9), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(144), (36), (22), (4), (4), (2), (2), (2)
(123), (16), (5)
This RIPK2 antibody is un-conjugated
(6), (5), (4), (2), (2), (2)
Western Blotting (WB)
(131), (70), (40), (20), (16), (14), (3), (3), (3), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen KLH-conjugated synthetic peptide corresponding to amino acids 11-30 of human RICK
Purification Protein G Chromatography
Alternative Name RIPK2 (RIPK2 Antibody Abstract)
Background Apoptosis is mediated by death domain (DD) and /or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A CARD containing serine/threonine kinase, designated RICK/RIP2/CARDIAK (for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively (1-3). RICK contains an N- terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kB and JUNK. RICK interacts with members of the TRAF family, CLARP, and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis. Alternate Names: RIP2, CARDIAK.
UniProt O43353
Research Area Apoptosis/Necrosis, Signaling
Pathways TCR Signaling, Neurotrophin Signaling Pathway
Application Notes Western blot (1/1,000, In K562, a ~55 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-RIPK2 antibody (Receptor-Interacting Serine-threonine Kinase 2) (AA 11-30) (ABIN123430) Western blot analysis for RICK using ABIN123430 at 1:1000 dilution against 10 ug/lane...
General Thome, Hofmann, Burns et al.: "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1." in: Current biology : CB, Vol. 8, Issue 15, pp. 885-8, 1998 (PubMed).

McCarthy, Ni, Dixit: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16968-75, 1998 (PubMed).

Inohara, del Peso, Koseki et al.: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12296-300, 1998 (PubMed).

Catalog No. ABIN123430

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