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Details for Product No. ABIN123430

Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 11-30) antibody

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Synonyms 2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2, GIG30, RIPK2
»Alternatives AA 11-30
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN123430
Quantity 0.1 mg
599.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH-conjugated synthetic peptide corresponding to amino acids 11-30 of human RICK
Purification Protein G Chromatography
Alternative Name RIPK2
Background Apoptosis is mediated by death domain (DD) and /or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A CARD containing serine/threonine kinase, designated RICK/RIP2/CARDIAK (for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively (1-3). RICK contains an N- terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kB and JUNK. RICK interacts with members of the TRAF family, CLARP, and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced apoptosis. Alternate Names: RIP2, CARDIAK.
UniProt O43353
Research Area Apoptosis/Necrosis, Signaling
Application Notes Western blot (1/1,000, In K562, a ~55 kDa band is observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Inohara, del Peso, Koseki et al.: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12296-300, 1998 (PubMed).

McCarthy, Ni, Dixit: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16968-75, 1998 (PubMed).

Thome, Hofmann, Burns et al.: "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1." in: Current biology : CB, Vol. 8, Issue 15, pp. 885-8, 1998 (PubMed).

Alternatives for antigen "Receptor-Interacting Serine-threonine Kinase 2 (RIPK2)", type "Antibodies"
Hosts (74), (15), (5)
Reactivities (93), (37), (20), (1), (1), (1)
Applications (91), (47), (23), (21), (12), (7), (3), (2), (1), (1), (1), (1)
Epitopes (14), (14), (7), (5), (4), (2), (2), (2), (2), (1)