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Details for Product No. ABIN123440

Sirtuin 7 (SIRT7) (AA 35-51), (AA 361-377) antibody

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Antigen
Synonyms SIR2L7, SIRT7, LOC796135
Epitope
»Alternatives AA 35-51, AA 361-377
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN123440
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Discontinued
Immunogen Mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of humanSIRT7
Characteristics Synonyms: SIRT-7, SIR2-like protein 7, SIR2L7, sirtuin type 7, sirtuin 7, sirtuin-7, sirtuin (silent matingtype information regulation 2, S.cerevisiae, homolog) 7, NAD-dependent deacetylasesirtuin-7
Purification Protein G Chromatography
Alternative Name SIRT7
Background SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and arepresent in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain,which contains a series of sequence motifs conserved in organisms ranging from bacteriato humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD andpossibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yetcompletely understood but recent reports of histone-activated Sir2-mediated NADmetabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possiblecoupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the Nepsilon-acetyl-lysine groups of acetylated histones
Gene ID 51547
UniProt Q9NRC8
Research Area Cancer, Chromatin Binding Proteins, Transcription Factors, Proteases
Application Notes Western blot (1 - 3 ug/ml). Recommended Positive Control: human liver or PBMC. There is no corresponding 40 kD band seen in mouse or rat liver cell lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2 % gelatin, 0.05 % sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Frye: "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity." in: Biochemical and biophysical research communications, Vol. 260, Issue 1, pp. 273-9, 1999 (PubMed).

Landry, Sutton, Tafrov et al.: "The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 11, pp. 5807-11, 2000 (PubMed).

Frye: "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins." in: Biochemical and biophysical research communications, Vol. 273, Issue 2, pp. 793-8, 2000 (PubMed).

Alternatives for antigen "Sirtuin 7 (SIRT7)", type "Antibodies"
Hosts (52), (9), (3)
Reactivities (56), (32), (30), (14), (13), (12), (2)
Applications (50), (24), (13), (10), (9), (7), (3), (2), (2), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (3), (2), (2), (1), (1), (1), (1), (1)
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