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Details for Product No. ABIN123458

Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 116-132) antibody

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Antigen
Synonyms CD267, CVID, CVID2, RYZN, TACI, TNFRSF14B, 1200009E08Rik, Taci, TNFRSF13B
Epitope
»Alternatives AA 116-132
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 7 references available
Catalog no. ABIN123458
Quantity 0.1 mg
Price
445.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 116-132 of human TACI.
Purification Protein G Chromatography
Alternative Name CD267 / TACI
Background Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approximately 32 kDa.
UniProt O14836
Application Notes Western blot: 0.1-0.5 ug/ml. Human spleen cells, Raw cells, or Daudi cells can be used as positive control. Flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Laabi, Gras, Carbonnel et al.: "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma." in: The EMBO journal, Vol. 11, Issue 11, pp. 3897-904, 1992 (PubMed).

Gras, Laabi, Linares-Cruz et al.: "BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes." in: International immunology, Vol. 7, Issue 7, pp. 1093-106, 1996 (PubMed).

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Mukhopadhyay, Ni, Zhai et al.: "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15978-81, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Marsters, Yan, Pitti et al.: "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI." in: Current biology : CB, Vol. 10, Issue 13, pp. 785-8, 2000 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B)", type "Antibodies"
Hosts (62), (14), (10), (8)
Reactivities (71), (26), (18)
Applications (49), (41), (28), (20), (15), (10), (6), (3), (3), (2), (2), (1)
Conjugates (9), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (14), (5)
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