Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 116-132) antibody

Details for Product No. ABIN123458
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Antigen
Synonyms CD267, CVID, CVID2, RYZN, TACI, TNFRSF14B, 1200009E08Rik, Taci, TNFRSF13B
Epitope
AA 116-132
(15), (4)
Reactivity
Human, Mouse (Murine)
(65), (26), (18)
Host
Rabbit
(62), (12), (8), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(44), (38), (27), (20), (14), (11), (6), (4), (3), (2), (1), (1)
Pubmed 7 references available
Catalog no. ABIN123458
Quantity 0.1 mg
Price
456.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide corresponding to amino acids 116-132 of human TACI.
Purification Protein G Chromatography
Alternative Name CD267 / TACI
Background Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approximately 32 kDa.
UniProt O14836
Application Notes Western blot: 0.1-0.5 ug/ml. Human spleen cells, Raw cells, or Daudi cells can be used as positive control. Flow cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B) (AA 116-132) antibody Western blot analysis of 0.1 ug/ml of TACI in 10 ug/lane of Daudi lysate. A protein band of approximately 32 kD is detected.
General Laabi, Gras, Carbonnel et al.: "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma." in: The EMBO journal, Vol. 11, Issue 11, pp. 3897-904, 1992 (PubMed).

Gras, Laabi, Linares-Cruz et al.: "BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes." in: International immunology, Vol. 7, Issue 7, pp. 1093-106, 1996 (PubMed).

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Mukhopadhyay, Ni, Zhai et al.: "Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 15978-81, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Marsters, Yan, Pitti et al.: "Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI." in: Current biology : CB, Vol. 10, Issue 13, pp. 785-8, 2000 (PubMed).

Hosts (62), (12), (8), (6)
Reactivities (65), (26), (18)
Applications (44), (38), (27), (20), (14), (11), (6), (4), (3), (2), (1), (1)
Conjugates (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (15), (4)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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