Toll-Like Receptor 7 (TLR7) (AA 650-700) antibody

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AA 650-700
(34), (18), (13), (13), (13), (12), (7), (6), (6), (6), (6), (6), (6), (6), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(194), (86), (29), (2), (2), (2), (2), (1), (1), (1), (1)
(180), (38), (3), (1)
(13), (11), (8), (7), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(161), (83), (48), (36), (32), (15), (15), (11), (8), (6), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen KLH-conjugated synthetic peptide corresponding to a portion of amino acids 650-700 of human TLR7
Purification Protein G Chromatography
Alternative Name TLR7 (TLR7 Antibody Abstract)
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response. Alternate Names: Toll-like Receptor 7, TLR-7.
UniProt Q9NYK1
Research Area Immunology, Innate Immunity, Transcription Factors, Signaling, Inflammation
Pathways TLR Signaling
Application Notes Flow cytometry (Intracellular, 0.5-2 ug/1x10e6 cells). Flow cytometry (Cell Surface, see Wong et al, 2007). Western blot (see Wong et al, 2007). Immunohistochemistry (frozen, 1:20, see Chen et al., 2005). Recommended positive control: Ramos cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 7 (TLR7) (AA 650-700) antibody (ABIN123468) Intracellular staining by FACS analysis of TLR7 in Ramos cells (A) using ABIN123468 a...
General Chen, Nagaraju, Bakay et al.: "Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy." in: Neurology, Vol. 65, Issue 6, pp. 826-34, 2005 (PubMed).

Muzio, Natoli, Saccani et al.: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

Medzhitov, Janeway: "Innate immunity: the virtues of a nonclonal system of recognition." in: Cell, Vol. 91, Issue 3, pp. 295-8, 1997 (PubMed).