XiAP Associated Factor 1 (XAF1) (AA 201-218) antibody

Details for Product No. ABIN123482
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AA 201-218
(16), (15), (14), (8), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(60), (31), (7)
(72), (4)
(2), (2), (2), (2), (2), (2), (1), (1)
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(72), (23), (18), (12), (4), (4), (3), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN123482
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Immunogen A mixture of KLH-conjugated synthetic peptides corresponding to aa 201-218 and 301-317 of human XAF1 AA Sequence:NQTSTMEKDVRPKTRSIN / QLDLEKERYYKFKRFHF
Purification Protein G Chromatography.
Alternative Name XAF1
Background The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
UniProt Q6GPH4
Application Notes Western blot: 1.0 - 2.0 ug/ml. Immunohistochemistry (paraffin): 1/100. Recommended positive control: human liver (a 34 kDa band should be observed). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-XiAP Associated Factor 1 (XAF1) (AA 201-218) antibody Western blot analysis of XAF1 in human liver lysates using ABIN123482 at 1 ug/ml.
General Davis, Bressler, Aiello et al.: "Comparison of Time-Domain OCT and Fundus Photographic Assessments of Retinal Thickening in eyes with Diabetic Macular Edema." in: Investigative ophthalmology & visual science, 2008 (PubMed).

Holcik, Gibson, Korneluk: "XIAP: apoptotic brake and promising therapeutic target." in: Apoptosis : an international journal on programmed cell death, Vol. 6, Issue 4, pp. 253-61, 2001 (PubMed).

Liston, Fong, Kelly et al.: "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity." in: Nature cell biology, Vol. 3, Issue 2, pp. 128-33, 2001 (PubMed).

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