anti-NFKBIZ antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta) (AA 684-699)

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AA 684-699, AA 285-298
(5), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Human, Monkey, Mouse (Murine), Rat (Rattus)
(30), (27), (13)
(33), (5), (4)
This NFKBIZ antibody is un-conjugated
(3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(23), (11), (8), (7), (4), (3)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen Synthetic peptides corresponding to amino acids 684-699 and 285-298 of Mouse IkBzproteinAA Sequence: RKGADPSTRNLENEQP (684-699), YQYSPQTQNMQQPP (258-298)
Characteristics Synonyms: I-kappa-B-zeta, IkB-zeta, IkappaBzeta, INAP, MAIL, NF-kappa-B inhibitor zeta, Moleculepossessing ankyrin repeats induced by lipopolysaccharide, IL-1 inducible nuclearankyrin-repeat protein
Purification Protein G Chromatography.
Alternative Name NFKBIZ / IKBZ (NFKBIZ Antibody Abstract)
Background IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclearprotein that is highly homologous to the IkappaB family member Bcl-3. Transcription ofIkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in culturedB-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes,fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with theNF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit theDNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
Gene ID 64332
UniProt Q9BYH8
Pathways NF-kappaB Signaling
Application Notes Western Blot: 1-3 µg/ml. Recommended Positive Control: RAW. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-NFKBIZ antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta) (AA 684-699) (ABIN123508) Western blot analysis of IkappaBz using antibody ABIN123508 at 3 ug/ml in mouse RAW c...
General Ito, Okada, Mochida et al.: "Molecular cloning of bullfrog corticotropin-releasing factor (CRF): effect of homologous CRF on the release of TSH from pituitary cells in vitro." in: General and comparative endocrinology, Vol. 138, Issue 3, pp. 218-27, 2004 (PubMed).

Kitamura, Matsushita, Iwanaga et al.: "Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages." in: Archives of histology and cytology, Vol. 66, Issue 1, pp. 53-62, 2003 (PubMed).

Yamazaki, Muta, Takeshige: "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei." in: The Journal of biological chemistry, Vol. 276, Issue 29, pp. 27657-62, 2001 (PubMed).

Catalog No. ABIN123508
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