CD207 Molecule, Langerin (CD207) (AA 36-44) antibody

Details for Product No. ABIN123512
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Antigen
Epitope
AA 36-44
(5), (2), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(93), (81), (55), (10)
Host
Rabbit
(56), (34), (29)
Clonality
Polyclonal
Conjugate
Un-conjugated
(17), (17), (15), (14), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(88), (40), (30), (25), (14), (7), (6), (6), (6), (5), (4), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN123512
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Immunogen Amino acids 36-44 of mouse Langerin
Isotype IgG
Purification Protein G Chromatography
Alternative Name CD207 / Langerin
Background Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation. Alternate Names: CD207.
UniProt Q8VBX4
Research Area CD Antigens
Application Notes Western Blot: 1 - 3 ug/ml. A protein band of ~36 kDa is detected in mouse lung tissue lysate. Pre-incubation with the immunizing peptide completely removes langerin reactivity from ABIN123512. IHC (FFPE): 2.5-5 ug/ml. Flow (Intracellular): see Ness et al for details. Recommended positive control: Mouse lung tissue lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.05% BSA as stabilizer and 0.05% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-CD207 Molecule, Langerin (CD207) (AA 36-44) antibody Western blot analysis of langerin in mouse lung tissue lysate using 2 ug/ml of ABIN123512. Lane 1, Without blocking peptide, Lane 2, With blocking peptide.
General Valladeau, Ravel, Dezutter-Dambuyant et al.: "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules." in: Immunity, Vol. 12, Issue 1, pp. 71-81, 2000 (PubMed).

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