anti-IL20RA antibody (Interleukin 20 Receptor alpha) (Extracellular Domain)

Details for Product anti-IL20RA Antibody No. ABIN123535
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Extracellular Domain, AA 159-175
(12), (6), (6), (5), (4), (2), (1), (1), (1), (1), (1), (1)
Human, Monkey, Mouse (Murine), Rat (Rattus)
(38), (22), (14)
(41), (2), (1)
This IL20RA antibody is un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Flow Cytometry (FACS)
(25), (18), (11), (10), (10), (4), (2), (2), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Immunogen Amino acids 159-175 of Human IL-20RA protein (extracellular domain)Remarks: This sequence is 100% homologous in Human and Chimp, and 82% homologousin Mouse and Rat.
Characteristics Synonyms: IL-20R-alpha, IL-20R1, ZCYTOR7, Interleukin-20 receptor alpha chain, Cytokine receptorclass-II member 8, Cytokine receptor family 2 member 8
Purification Protein G Chromatography.
Alternative Name IL20RA (IL20RA Antibody Abstract)
Background IL20RA, is a subunit of IL20R, a member of Cytokine Class II receptor super family. Itconsists of a central transmembrane domain and functionally induces IL20 and IL26signaling in epithelial cells and keratinocytes. It associates with IL-20RB and forms afunctional receptor complex for IL20, IL19, and IL24. It also associates with IL-10RB andforms a unique heterodimeric functional receptor complex for IL-26. Upon ligand binding, itinduces signaling through activation of STAT3 and STAT1. IL20RA is specifically expressedin skin suggesting a prominent role in growth and proliferation of keratinocytes.
Gene ID 53832
UniProt Q9UHF4
Application Notes Western blot analysis: 1-3 µg/ml. Both the expect ~70 kD band and an unknown ~90 kDband are seen in A375 cell lysate and are blocked by the immunizing peptide. The ~90 kDband alone is seen in A431 cell lysate, and it is also blocked by the immunizing peptide). Flow Cytometry: 2-5 µg/10e6 cells (Permeabilization of the cells may affect antibodybinding). Recommended Positive Control: A375. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-IL20RA antibody (Interleukin 20 Receptor alpha) (Extracellular Domain) (ABIN123535) Cell-surface flow cytometry analysis of IL-20RA in A375 cells using ABIN123535 at 5 u...
Western Blotting (WB) image for anti-IL20RA antibody (Interleukin 20 Receptor alpha) (Extracellular Domain) (ABIN123535) Western blot analysis of IL-20RA in A375 cell lysate in the (A) absence and (B) prese...
General Blumberg, Conklin, Xu et al.: "Interleukin 20: discovery, receptor identification, and role in epidermal function. ..." in: Cell, Vol. 104, Issue 1, pp. 9-19, 2001 (PubMed).

Catalog No. ABIN123535
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