Interleukin 20 Receptor alpha (IL20RA) (Extracellular Domain), (AA 159-175) antibody

Details for Product No. ABIN123535
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Antigen
Epitope
Extracellular Domain, AA 159-175
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
(38), (21), (17), (17), (17)
Host
Rabbit
(37), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(22), (14), (13), (8), (7), (6), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN123535
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Immunogen Amino acids 159-175 of Human IL-20RA protein (extracellular domain)Remarks: This sequence is 100% homologous in Human and Chimp, and 82% homologousin Mouse and Rat.
Characteristics Synonyms: IL-20R-alpha, IL-20R1, ZCYTOR7, Interleukin-20 receptor alpha chain, Cytokine receptorclass-II member 8, Cytokine receptor family 2 member 8
Purification Protein G Chromatography.
Alternative Name IL20RA
Background IL20RA, is a subunit of IL20R, a member of Cytokine Class II receptor super family. Itconsists of a central transmembrane domain and functionally induces IL20 and IL26signaling in epithelial cells and keratinocytes. It associates with IL-20RB and forms afunctional receptor complex for IL20, IL19, and IL24. It also associates with IL-10RB andforms a unique heterodimeric functional receptor complex for IL-26. Upon ligand binding, itinduces signaling through activation of STAT3 and STAT1. IL20RA is specifically expressedin skin suggesting a prominent role in growth and proliferation of keratinocytes.
Gene ID 53832
UniProt Q9UHF4
Application Notes Western blot analysis: 1-3 µg/ml. Both the expect ~70 kD band and an unknown ~90 kDband are seen in A375 cell lysate and are blocked by the immunizing peptide. The ~90 kDband alone is seen in A431 cell lysate, and it is also blocked by the immunizing peptide). Flow Cytometry: 2-5 µg/10e6 cells (Permeabilization of the cells may affect antibodybinding). Recommended Positive Control: A375. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.2% gelatin and 0.05% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Interleukin 20 Receptor alpha (IL20RA) (Extracellular Domain), (AA 159-175) antibody Cell-surface flow cytometry analysis of IL-20RA in A375 cells using ABIN123535 at 5 ug/106 cells. The shaded histogram represents cells only, green represents isotype control, and purple represents anti-IL-20RA antibody.
anti-Interleukin 20 Receptor alpha (IL20RA) (Extracellular Domain), (AA 159-175) antibody (2) Western blot analysis of IL-20RA in A375 cell lysate in the (A) absence and (B) presence of blocking peptide using ABIN123535 at 2 ug/ml.
General Blumberg, Conklin, Xu et al.: "Interleukin 20: discovery, receptor identification, and role in epidermal function." in: Cell, Vol. 104, Issue 1, pp. 9-19, 2001 (PubMed).

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