anti-p53 antibody (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN123800, Supplier: Login to see New
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Antigen
Synonyms tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
Alternatives
Reactivity
Human
(1966), (365), (289), (81), (33), (12), (12), (11), (11), (10), (9), (7), (7), (6), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1)
Host
Rabbit
(1342), (719), (8), (6), (3), (1), (1)
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
(57), (48), (31), (30), (21), (21), (17), (15), (15), (14), (14), (14), (14), (14), (14), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1)
Application
Western Blotting (WB)
(1571), (643), (565), (419), (387), (366), (258), (160), (138), (107), (55), (35), (33), (24), (19), (18), (18), (16), (14), (11), (9), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 7 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 5 to 6 Business Days
Specificity Alpha-p53 reacts with the p53 protein in HeLa nuclear extract by Western blotting.
Alternative Name Tumor Supressor Protein p53 (TP53 Antibody Abstract)
Background P53 was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. alpha-p53 is an affinity-purified rabbit polyclonal antibody raised against the recombinant p53 protein.
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling
Application Notes Recommended dilution range for Western blot analysis: 1:200 - 1:1000.
Restrictions For Research Use only
Format Liquid
Storage -80 °C
Background publications Finlay, Hinds, Levine: "The p53 proto-oncogene can act as a suppressor of transformation." in: Cell, Vol. 57, Issue 7, pp. 1083-93, 1989 (PubMed).

Raycroft, Wu, Lozano: "Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1049-51, 1990 (PubMed).

Fields, Jang: "Presence of a potent transcription activating sequence in the p53 protein." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1046-9, 1990 (PubMed).

Baker, Markowitz, Fearon et al.: "Suppression of human colorectal carcinoma cell growth by wild-type p53." in: Science (New York, N.Y.), Vol. 249, Issue 4971, pp. 912-5, 1990 (PubMed).

Michalovitz, Halevy, Oren: "Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53." in: Cell, Vol. 62, Issue 4, pp. 671-80, 1990 (PubMed).

Hollstein, Sidransky, Vogelstein et al.: "p53 mutations in human cancers." in: Science (New York, N.Y.), Vol. 253, Issue 5015, pp. 49-53, 1991 (PubMed).

Bennett, Hollstein, Hsu et al.: "Mutational spectra and immunohistochemical analyses of p53 in human cancers." in: Chest, Vol. 101, Issue 3 Suppl, pp. 19S-20S, 1992 (PubMed).

Catalog No. ABIN123800
$428.51
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