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Tumor Protein P53 (TP53) antibody

Details for Product No. ABIN123800
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Antigen
Synonyms tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
Reactivity
Human
(1340), (311), (266), (78), (76), (66), (48), (24), (15), (12), (8), (6), (5), (5), (4), (3), (3), (2), (2), (2), (1)
Host
Rabbit
(990), (426), (7), (5), (3), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(36), (31), (22), (16), (16), (16), (16), (16), (16), (16), (16), (11), (11), (11), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(1063), (487), (354), (333), (264), (215), (160), (150), (111), (85), (22), (22), (14), (7), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 7 references available
Quantity 50 µg
Shipping to United States (Change)
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Catalog No. ABIN123800
457.38 $
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Specificity Alpha-p53 reacts with the p53 protein in HeLa nuclear extract by Western blotting.
Alternative Name Tumor Supressor Protein p53
Background P53 was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. alpha-p53 is an affinity-purified rabbit polyclonal antibody raised against the recombinant p53 protein.
Application Notes Recommended dilution range for Western blot analysis: 1:200 - 1:1000.
Restrictions For Research Use only
Format Liquid
Storage -80 °C
General Bennett, Hollstein, Hsu et al.: "Mutational spectra and immunohistochemical analyses of p53 in human cancers." in: Chest, Vol. 101, Issue 3 Suppl, pp. 19S-20S, 1992 (PubMed).

Hollstein, Sidransky, Vogelstein et al.: "p53 mutations in human cancers." in: Science (New York, N.Y.), Vol. 253, Issue 5015, pp. 49-53, 1991 (PubMed).

Michalovitz, Halevy, Oren: "Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53." in: Cell, Vol. 62, Issue 4, pp. 671-80, 1990 (PubMed).

Baker, Markowitz, Fearon et al.: "Suppression of human colorectal carcinoma cell growth by wild-type p53." in: Science (New York, N.Y.), Vol. 249, Issue 4971, pp. 912-5, 1990 (PubMed).

Fields, Jang: "Presence of a potent transcription activating sequence in the p53 protein." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1046-9, 1990 (PubMed).

Raycroft, Wu, Lozano: "Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1049-51, 1990 (PubMed).

Finlay, Hinds, Levine: "The p53 proto-oncogene can act as a suppressor of transformation." in: Cell, Vol. 57, Issue 7, pp. 1083-93, 1989 (PubMed).

Validation Images
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