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Tumor Protein P53 (TP53) antibody

Antigen

Tumor Protein P53 (TP53)
Synonyms p53, LFS1, TRP53, FLJ92943, P53, Trp53, MGC112612, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919, TP53, bbl, bfy, bhy, p44, Tp53, tp53
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
7 references available
Catalog no. ABIN123800
Quantity 50 µg
Price 457.38 $   Plus shipping costs $45.00
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Additional Information
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Alternative name Tumor Supressor Protein p53
Format Liquid
Description P53 was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. alpha-p53 is an affinity-purified rabbit polyclonal antibody raised against the recombinant p53 protein.
Specificity Alpha-p53 reacts with the p53 protein in HeLa nuclear extract by Western blotting.

Application Details
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Application Notes Recommended dilution range for Western blot analysis: 1:200 - 1:1000.
Storage store at -80 °C, avoid freeze/thaw cycles. Shipped on dry ice. Shelf Life: 12 months.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Bennett, Hollstein, Hsu et al.: "Mutational spectra and immunohistochemical analyses of p53 in human cancers." in: Chest, Vol. 101, Issue 3 Suppl, pp. 19S-20S, 1992 (PubMed).

Hollstein, Sidransky, Vogelstein et al.: "p53 mutations in human cancers." in: Science (New York, N.Y.), Vol. 253, Issue 5015, pp. 49-53, 1991 (PubMed).

Michalovitz, Halevy, Oren: "Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53." in: Cell, Vol. 62, Issue 4, pp. 671-80, 1990 (PubMed).

Baker, Markowitz, Fearon et al.: "Suppression of human colorectal carcinoma cell growth by wild-type p53." in: Science (New York, N.Y.), Vol. 249, Issue 4971, pp. 912-5, 1990 (PubMed).

Fields, Jang: "Presence of a potent transcription activating sequence in the p53 protein." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1046-9, 1990 (PubMed).

Raycroft, Wu, Lozano: "Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1049-51, 1990 (PubMed).

Finlay, Hinds, Levine: "The p53 proto-oncogene can act as a suppressor of transformation." in: Cell, Vol. 57, Issue 7, pp. 1083-93, 1989 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Tumor Protein P53 (TP53)", type "Antibodies"
Hosts Rabbit (473), Mouse (290), Sheep (4), Escherichia Coli (E. coli) (1), Rat (1), Recombinant (1)
Reactivities Human (706), Mouse (Murine) (176), Rat (Rattus) (146), Cow (Bovine) (69), Dog (Canine) (49), Horse (Equine) (48), Pig (Porcine) (43), Sheep (Ovine) (41), Monkey (40), Guinea Pig (10), Primate (8), Chicken (7), Rabbit (7), Cat (Feline) (5), Hamster (5), Mammalian (2), Xenopus laevis (2), Bird (Avian) (1)
Applications Western Blotting (WB) (542), ELISA (232), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (215), Immunofluorescence (IF) (199), Immunoprecipitation (IP) (162), Immunohistochemistry (IHC) (147), Flow Cytometry (FACS) (93), Immunocytochemistry (ICC) (59), Immunohistochemistry (Frozen Sections) (IHC (fro)) (50), Immunohistochemistry (Fixed) (IHC (fx)) (22), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (10), Dot Blot (Dot) (9), Chromatin Immunoprecipitation (ChiP) (8), Gel Shift (GS) (5), Radioimmunoassay (RIA) (4), Immunoelectron Microscopy (IEM) (2), Affinity Purification (AP) (1), Cellular Assay (CA) (1), Dot Blot (DB) (1), ELISA (Capture) (1), ELISA (Detection) (1), Immunoassay (IA) (1), Immunostaining (ISt) (1), Transfected cell culture (TCC) (1)
Conjugates FITC (17), Alexa Fluor 350 (15), Alexa Fluor 488 (15), Alexa Fluor 555 (15), Alexa Fluor 647 (15), Biotin (13), PE,Cy5.5 (13), HRP (4), PE (3), RPE (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE-Cy3 (2), PE-Cy5 (2), PE-Cy5.5 (2), PE-Cy7 (2), Un-conjugated (2)
Epitopes AA 20-25 (20), N-Term (18), pSer37 (17), pSer46 (16), C-Term (15), pSer15 (15), pSer315 (15), pSer33 (14), pThr18 (14), AA 1-393 (13), pSer20 (13), pSer6 (13), pSer392 (12), pSer9 (11), pSer376 (7), pThr55 (7), Ser37 (5), Ser46 (5), pThr81 (5), AA 14-389 (4), AA 371-380 (4), Ser315 (4), AA 10-16 (3), AA 26-35 (3), AA 32-79 (3), AA 35-45 (3), AA 56-65 (3), pSer378 (3), AA 16-25 (2), AA 16-30 (2), AA 181-190 (2), AA 213-217 (2), AA 306-393 (2), AA 378-393 (2), AA 46-53 (2), AA 46-55 (2), AA 88-109 (2), Ser15 (2), Ser33 (2), Ser6 (2), Thr18 (2), Thr55 (2), acLys317 (2), acLys379 (2), acLys382 (2), acLys386 (2), AA 1-12 (1), AA 14-289 (1), AA 15-40 (1), AA 156-214 (1), AA 361-382 (1), AA 367-381 (1), AA 37-45 (1), AA 37-5 (1), AA 383-393 (1), Internal Region (1), Mutant (1), Mutant,AA 213-217 (1), Ser15,Phosphospecific (1), Ser20 (1), Ser392 (1), Wild type,Mutant (1), Wild type,Mutant,AA 32-79 (1), Wild type,Mutant,AA 370-378 (1), Wildtype (1), acLys373 (1), pSer299 (1), pSer332 (1), pSer366 (1), pSer371 (1), pSer392,AA 378-393 (1), pSer63 (1), pSer95 (1), pThr387 (1), pTyr757 (1), phospho (1)