APO-1/Fas (CD95) antibody

Antigen: APO-1/Fas (CD95)

Clonality: Monoclonal (SM1-1)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Blocking Antibody (Inhibition), Western Blotting (WB)

Catalog no.: ABIN123905

Additional Information

Immunogen: human APO-1/Fas (CD95)

Format: Protein A purified

Isotype: IgG2a  (Matching secondary antibodies)

Clone: SM1-1

Application Details

Buffer: PBS

Storage: 2-8 °C until expiry as indicated on the label. After opening aliquote contents and freeze at -20 °C.

Research Area: CD Antigens, Apoptosis/Necrosis, Virology

Restrictions: For Research Use only

Publications

Publications: Gajate, Mollinedo: "The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells." in: Blood, Vol. 98, Issue 13, pp. 3860-3, 2001 (PubMed).

Wood, Goodman, Vassilev et al.: "CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants." in: European journal of haematology, Vol. 70, Issue 3, pp. 156-71, 2003 (PubMed).

Gajate, Del Canto-Janez, Acuna et al.: "Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis." in: The Journal of experimental medicine, Vol. 200, Issue 3, pp. 353-65, 2004 (PubMed).

Gajate, Mollinedo: "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11641-7, 2005 (PubMed).

Nieto-Miguel, Gajate, Mollinedo: "Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells." in: The Journal of biological chemistry, Vol. 281, Issue 21, pp. 14833-40, 2006 (PubMed).