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Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibody
| Antigen | Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) |
| Synonyms | BWS, WBS, p57, BWCR, KIP2, cb961, p27Xic1-a, zgc:86618 |
| Clonality | Monoclonal (KP39) |
| Host |
 Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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3 references available |
| Catalog no. | ABIN125246 |
| Quantity |
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| Price | 488.40 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 3 to 4 Business Days |
Additional Information
| Alternative name | p57Kip2 |
| Immunogen | BALB/C mice were immunized with a recombinant p57 KIP2. |
| Isotype | IgG2b |
| Clone | KP39 |
| Specificity | This antibody is specific to a protein of 57 kD known as p57Kip2 a cell cycle regulatory mitotic inhibitor. This antibody does not cross react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and is negative regulator of cell proliferation. |
Application Details
| Application Notes | Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Suitable for formalin/paraffin tissues. Positive Control: Colon carcinoma. Cellular localization: Nuclear |
| Concentration | 100ug/ml approximately |
| Buffer | This antibody is supplied as purified immunoglobulin containing sodium azide as preservative. |
| Storage | Store the antibody at 4-8o c. Do not use it beyond the expiration date stated on the label. |
| Research Area | Cancer, Cell Cycle |
| Restrictions | For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union |
Publications
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Matsuoka, Edwards, Bai et al.: "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene." in: Genes & development, Vol. 9, Issue 6, pp. 650-62, 1995 (PubMed).
Harper, Elledge: "Cdk inhibitors in development and cancer." in: Current opinion in genetics & development, Vol. 6, Issue 1, pp. 56-64, 1997 (PubMed). Dynlacht, Ngwu, Winston et al.: "Purification and analysis of CIP/KIP proteins." in: Methods in enzymology, Vol. 283, pp. 230-44, 1997 (PubMed). |
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Alternatives
Alternatives for antigen "Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C)", type "Antibodies"
| Hosts | Rabbit (72), Mouse (29) |
| Reactivities | Human (97), Mouse (Murine) (48), Rat (Rattus) (39), Cow (Bovine) (20), Sheep (Ovine) (18), Cat (Feline) (1), Chicken (1), Dog (Canine) (1) |
| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (37), Western Blotting (WB) (36), Immunofluorescence (IF) (35), ELISA (27), Immunoprecipitation (IP) (23), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunohistochemistry (IHC) (3), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (2), Flow Cytometry (FACS) (1) |
| Conjugates | Biotin (5), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2) |
| Epitopes | C-Term (19), pThr310 (19), N-Term (11), AA 303-316 (1), Internal Region (1), N-Term,AA 34-64 (1) |
