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Cyclin D1 (CCND1) antibody
| Antigen | Cyclin D1 (CCND1) |
| Synonyms |
BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, ...
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| Clonality | Monoclonal (SP4) |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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2 references available |
| Catalog no. | ABIN125287 |
| Quantity | 6ml (1 to 4 ug/ml) (Variants) |
| Price | 244.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 Business Days |
Additional Information
| Alternative name | Cyclin D1 |
| Immunogen | A synthetic peptide from C-terminus of human cyclin D1. |
| Format | Supernatant (prediluted) |
| Isotype | IgG (Matching secondary antibodies) |
| Clone | SP4 |
| Specificity | Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and / or cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). This antibody crossreacts with Human, mouse and rat. |
| Synonyms | BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317 |
Application Details
| Application Notes | Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Breast Carcinoma. Cellular localization: Nuclear |
| Concentration | 1 to 4 ug/ml |
| Buffer | This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. |
| Storage | Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label. |
| Research Area | Cell Cycle |
| Restrictions | For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union |
Publications
| Publications |
Cheuk, Wong, Wong et al.: "Consistent immunostaining for cyclin D1 can be achieved on a routine basis using a newly available rabbit monoclonal antibody." in: The American journal of surgical pathology, Vol. 28, Issue 6, pp. 801-7, 2004 (PubMed).
Klopstock, Katzenellenbogen, Pappo et al.: "HCV tumor promoting effect is dependent on host genetic background." in: PLoS ONE, Vol. 4, Issue 4, pp. e5025, 2009 (PubMed). |
Alternatives
Alternatives for antigen "Cyclin D1 (CCND1)", type "Antibodies"
| Hosts | Rabbit (51), Mouse (27) |
| Reactivities | Human (67), Rat (Rattus) (37), Mouse (Murine) (32), Monkey (4), Dog (Canine) (2), Guinea Pig (2), Rabbit (2), Cow (Bovine) (1), Orang-Utan (1), Sheep (Ovine) (1) |
| Applications | Western Blotting (WB) (63), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (30), Immunoprecipitation (IP) (20), Immunohistochemistry (IHC) (14), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), ELISA (12), Enzyme Immunoassay (EIA) (9), Flow Cytometry (FACS) (8), Immunocytochemistry (ICC) (4), Immunofluorescence (IF) (4), ELISA (Detection) (3), Dot Blot (Dot) (1), Functional Studies (Func) (1) |
| Epitopes | C-Term (3), N-Term (2), Ab-286 (1), Center (1), S90 (1), pThr286 (1) |
