Matrix Metalloproteinase 11 (MMP11) antibody

Antigen: Matrix Metalloproteinase 11 (MMP11)

Synonyms: MMP-X1, MTMMP1, MT1-MMP, MMP18, RASI-1, ST3, Stmy3, MGC123370, MMP11, MMP19

Clonality: Monoclonal (SL3-05)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN125490

Additional Information

Immunogen: BALB/C mice were immunized with a recombinant protein corresponding to active form of human MMP-11

Format: Purified

Isotype: IgG1 kappa  (Matching secondary antibodies)

Clone: SL3-05

Specificity: This antibody with a protein of 60 kD (latent), 47 kD (active) and 35 kD (degradation product). Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. MMP-11 is localized on the long arm of chromosome 22. MMP-11 gene was originally identified on the basis that it is expressed specifically in stromal cells surrounding invasive breast carcinomas. MMP-11 is expression is found more specifically in malignant tumors than in benign ones.

Application Details

Application Notes: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. This antibody is suitable for formalin fixed paraffin tissue sections. No special pretreatment is required. Positive Control: Placenta. Cellular localization: Cytoplasmic

Concentration: 100ug/ml approximately

Buffer: This antibody is supplied as purified ascites containing sodium azide as preservative.

Storage: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Research Area: Extracellular Matrix

Restrictions: For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Images

Formalin fixed paraffin embedded human placenta stained with MMP-11 antibody