Linker For Activation of T Cells Family, Member 2 (LAT2) antibody

Antigen: Linker For Activation of T Cells Family, Member 2 (LAT2)

Synonyms: LAB, NTAL, WSCR5, WBSCR5, HSPC046, WBSCR15, LAT2, MGC139435

Clonality: Polyclonal

Host: Rabbit

Reactivity: Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Catalog no.: ABIN125755

Additional Information

Alternative name: NTAL / LAB

Immunogen: Recombinant mouse NTAL (aa 30-203).

Format: Purified

Description: NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NKcells, mast cells and macrophages. It is a negative regulator of early stages ofBCR-dependent B cell signaling and serves as a negative regulator also in mast cells.However, in mast cells, NTAL also contributes to some activation processes, partiallyoverlapping with LAT function.

Specificity: The polyclonal antibody reacts with Non-T cell Activation Linker (NTAL), also known as LAB(linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membranemicrodomains (rafts) of B cells, NK cells and myeloid cells. This antibody does not react with: Human.

Application Details

Application Notes: Western Blotting - Recommended dilution: 1 µg/ml. Positive control: mouse spleen. Sample preparation: Mix lysate with non-reducing SDS-PAGE sample buffer. Application note: Non-reducing conditions.

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from rabbit serum by protein-A afinity chromatography.

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Restrictions: For Research Use only

Images

Western Blotting