Keratin 2 (KRT2) antibody

Antigen: Keratin 2 (KRT2)

Synonyms: KRTE, KRT2A, KRT2E, MGC116967, MGC116968, Kb2, KRT2, K2E, krt2a, Krt2e, Krt2-2, Krt2-17, BB005427

Clonality: Monoclonal (Ks 2-398-3-1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)

Catalog no.: ABIN125984

Additional Information

Alternative name: Cytokeratin 2e

UniProt: P35908

Immunogen: Synthetic peptide (N-terminal amino acids Nos. 2-23) of human keratin K2 (MW 65,852).

Cross-Reactivity: Human

Isotype: IgG1

Clone: Ks 2-398-3-1

Description: Keratins are the major gene product of keratinocytes and form the intermediate filamentcytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 areexpressed. Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2E is expressed not only in this tissue but also in other regions, notably the epidermis coveringthe knee, thigh, and groin. It is not known whether these keratins simply replace theirrespective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerizewith another, as yet undiscovered keratin partner.

Characteristics: Synonyms: KRT2, KRT2A, KRT2E, Cytokeratin-2e, CK2e, K2e, Keratin-2, Keratin, type II cytoskeletal 2epidermal

Application Details

Application Notes: Immunoblotting. Immunohistochemistry: 1: 150. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Supernatant

Storage: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Research Area: Extracellular Matrix

Restrictions: For Research Use only

Publications

Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

Swensson, Langbein, McMillan et al.: "Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress." in: The British journal of dermatology, Vol. 139, Issue 5, pp. 767-75, 1999 (PubMed).