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Keratin 8 (KRT8) antibody (Biotin)

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Antigen
  • AA960620
  • AL022697
  • AU019895
  • CARD2
  • Card2
  • card2
  • cb186
  • CK-8
  • ck8
  • CK8
  • CYK8
  • cyk8
  • CYKER
  • DKFZp468F2127
  • DreK8
  • EndoA
  • K2C8
  • k2c8
  • K8
  • KERATIN8
  • KO
  • Krt-2.8
  • krt2-5
  • krt2-8
  • Krt2-8
  • KRT2-8
  • KRT8
  • MGC69490
  • sb:cb186
  • wu:fa20h05
  • wu:fa95h10
  • wu:fb96c06
  • zf-K8
  • zfk8
Reactivity
Hamster, Human, Mouse (Murine), Rat (Rattus)
706
152
117
62
50
40
35
30
20
14
14
8
4
4
3
2
1
1
1
1
Host
Mouse
492
227
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
29
17
15
14
13
12
12
11
11
11
11
11
11
11
11
9
9
4
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
521
272
239
234
164
161
152
145
116
26
14
12
12
4
2
2
2
1
Supplier
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Immunogen Cytoskeletal proteins from cultured HeLa cells
Clone Ks8-7
Isotype IgG1
Specificity This monoclonal Ks 8.7 antibody represents an excellent marker to discriminate simple epithelia from those of different origin. Polypeptide Reacting: Mr 52,500 polypeptide (keratin K8, formerly also designated cytokeratin 8) of human epithelia. Tumors specifically detected: All adeno-carcinoma tested, undifferentiated carcinoma, cervix and hepatocellular carcinoma. Tested Reactivities on cultured cells: MCF-7, RT 112, PLC.
Alternative Name Cytokeratin 8 (KRT8 Antibody Abstract)
Background Cytokeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.Synonyms: CK8, CYK8, Cytokeratin endo A, Cytokeratin-8, K8, KRT8, Keratin, Keratin-8, type II cytoskeletal 8
Gene ID 3856
NCBI Accession NP_002264
UniProt P05787
Research Area Cancer, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Western Blot. Immunocytology. Immunohistochemistry (1: 10) on frozen tissues and paraffin-embedded sections aftermicrowave treatment. Incubation time: 1 h at RT.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Stumptner, Fuchsbichler, Heid, Zatloukal, Denk: "Mallory body--a disease-associated type of sequestosome." in: Hepatology (Baltimore, Md.), Vol. 35, Issue 5, pp. 1053-62, 2002 (PubMed).

Gomi, Yokoyama, Fujimoto, Ikeda, Katoh, Itoh, Itohara: "Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions." in: Neuron, Vol. 14, Issue 1, pp. 29-41, 1995 (PubMed).

Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: "A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology." in: The Journal of pathology, Vol. 164, Issue 3, pp. 215-24, 1991 (PubMed).

Osborn, van Lessen, Weber, Klöppel, Altmannsberger: "Differential diagnosis of gastrointestinal carcinomas by using monoclonal antibodies specific for individual keratin polypeptides." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 55, Issue 4, pp. 497-504, 1986 (PubMed).

Moll, Franke, Schiller, Geiger, Krepler: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).