Lipoprotein Lipase antibody

Catalog No. ABIN125994

Product Details anti-Lipoprotein Lipase Antibody

Target: Lipoprotein Lipase (LPL)

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lipoprotein Lipase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Specificity: This Monoclonal antibody is directed against the CII binding site. Blocks the catalytic activity of Bovine milk lipase. A small partial cross-reactivity with Human Heparin Plasma Lipase activity was observed (Ref. 1).

Cross-Reactivity (Details): Species reactivity (tested):Bovine, weak cross-reactivity with Human.

Purification: Affinity Chromatography on Protein A

Immunogen: Purified Bovine Lipoprotein Lipase

Clone: Mab-7

Isotype: IgG1

Application Details

Application Notes: ELISA. Immunoblotting. Immunohistochemistry (1/10). Dilution buffer: PBS with 0.5 % BSA and 0.1 % Na-Azide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1 mL distilled water

Buffer: PBS, pH 7.4, 0.09 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Lipoprotein Lipase

Target: Lipoprotein Lipase (LPL)

Alternative Name: Lipoprotein Lipase (LPL Products)

Synonyms: HDLCQ11 antibody, LIPD antibody, fb62e04 antibody, fc49b03 antibody, wu:fb62e04 antibody, wu:fc49b03 antibody, LPL antibody, lipd antibody, hdlcq11 antibody, lpl antibody, LOC100223817 antibody, lipoprotein lipase antibody, LPL antibody, Lpl antibody, lpl antibody

Background: Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation.Synonyms: EC=3.1.1.34, LIPD, LPL

Gene ID: 4023

NCBI Accession: NP_000228

UniProt: P06858

Pathways: Lipid Metabolism