Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1) (C-Term) antibody

Details for Product No. ABIN126012
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Antigen
Synonyms HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, SLCO1B1
Epitope
C-Term
(16), (8), (4), (3), (2), (1), (1), (1)
Reactivity
Human
(30)
Host
Mouse
(26), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(30), (20), (3), (2), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 5 mL
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Catalog No. ABIN126012
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Immunogen Synthetic C-terminus (21 aa) of Human organic anion transporter SLC21A6 coupled to KLH
Clone MESL
Isotype IgM
Specificity The antibody reacts with OATP2/OATP1B1, Human organic anion transporter SLC21A6 (90 kD). It recognizes SCL21A6 transfected HEK293 cells, negative with HepG2 and PLC (cultured cell lines tested so far). Using Immunofluorescence Microscopy mESL stains the sinusoidal (basolateral) membranes in frozen sections of human liver, hepatocellular carcinoma and the human cell line HEK293 transfected with SLC21A6. In Western blot analyses the monoclonal antibody mESL reacts selectively with the 90 kD protein (after SDS-PAGE) present in the basolateral membrane fractions of human liver. According to a recent new nomenclature this hepatocytespecific protein is identical to OATP1B1 (see Ref. 2) also known as OATP-C.
Purification Supernatant
Alternative Name SLCO1B1 / OATP2
Background The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATPC, and LST1.
Alternate names: LST-1, LST1, Liver-specific organic anion transporter 1, OATP-2, OATP-C, OATPC, SLC21A6, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6, Solute carrier organic anion transporter family member 1B1
Gene ID 10599
NCBI Accession NP_006437
UniProt Q9Y6L6
Application Notes Immunofluorescence microscopy (Ready-to-use, Incubation time: 1 h at RT). Western blotting: for optimal detection of the glycosylated antigen sample boiling beforeSDS-PAGE is not recommended, alternatively, samples should be kept at 37C for 30 min(cf. Cui et al. ). Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for up to six months or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hagenbuch, Meier: "The superfamily of organic anion transporting polypeptides." in: Biochimica et biophysica acta, Vol. 1609, Issue 1, pp. 1-18, 2002 (PubMed).

Cui, König, Nies et al.: "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 4, pp. 527-38, 2003 (PubMed).

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