Keratin 2 (KRT2) (N-Term), (AA 2-23) antibody

Details for Product No. ABIN126065
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Synonyms KRT2, krt2a, CK-2e, K2e, KRT2A, KRT2E, KRTE, BB005427, Krt2-17, Krt2-2, Krt2e, Kb2, K2E
N-Term, AA 2-23
(8), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Human, Mouse (Murine)
(24), (8), (4), (3), (2), (1), (1)
Guinea Pig
(15), (13), (2)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(28), (17), (14), (12), (7), (7), (6), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN126065
511.50 $
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Immunogen Synthetic peptide (N-terminal aa 2-23) of human keratin K2.
Specificity The antiserum represents an excellent marker to study terminal epidermal differentiation. The mab is reactive with epidermal cells in uppermost suprabasal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co- localization with keratin K1). It is also strongly reactive on hyperkeratosis of diverse origin.The mab does not react with palate keratin K76.
Purification Serum
Alternative Name Cytokeratin 2e
Background Keratins are the major gene product of keratinocytes and form the intermediate filament cytoskeletal network in these cells. In cells of the upper spinous layer, KRT2E and KRT9 are expressed. Although the expression of KRT9 is limited to palmoplantar epidermis, KRT2E is expressed not only in this tissue but also in other regions, notably the epidermis covering the knee, thigh, and groin. It is not known whether these keratins simply replace their respective type I or type II counterpart in the preexisting KRT1/KRT10 network or dimerize with another, as yet undiscovered keratin partner.
Alternate names: CK2e, Cytokeratin-2e, K2e, KRT2, KRT2A, KRT2E, Keratin, Keratin-2, type II cytoskeletal 2 epidermal
Gene ID 9606
UniProt P35908
Research Area Extracellular Matrix
Application Notes Immunoblotting: 1: 5000 - 1: 10 000, ECL method. Immunohistochemistry on frozen sections: 1: 200. Immunohistochemistry on paraffin sections: 1: 100, 1 h at RT. Immunohistochemistry on cytological material. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

General Swensson, Langbein, McMillan et al.: "Specialized keratin expression pattern in human ridged skin as an adaptation to high physical stress." in: The British journal of dermatology, Vol. 139, Issue 5, pp. 767-75, 1999 (PubMed).

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