Keratin 8 (KRT8) antibody

Details for Product No. ABIN126068
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Antigen
Synonyms
ck8, cyk8, k2c8, card2, krt2-5, MGC69490, KRT8, DKFZp468F2127, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO, KRT2-8, AA960620, AL022697, AU019895, Card2, EndoA, Krt-2.8, Krt2-8, CYKER, DreK8, cb186, krt2-8, s ... show more
ck8, cyk8, k2c8, card2, krt2-5, MGC69490, KRT8, DKFZp468F2127, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO, KRT2-8, AA960620, AL022697, AU019895, Card2, EndoA, Krt-2.8, Krt2-8, CYKER, DreK8, cb186, krt2-8, sb:cb186, wu:fa20h05, wu:fa95h10, wu:fb96c06, zf-K8, zfk8, KERATIN8 show less
Reactivity
Human, Mouse (Murine)
(351), (107), (80), (23), (14), (13), (13), (8), (8), (7), (5), (4), (4), (3), (3), (1), (1), (1), (1)
Host
Guinea Pig
(218), (155), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(16), (9), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(245), (160), (107), (91), (84), (72), (62), (40), (28), (17), (6), (6), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN126068
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Immunogen Synthetic peptide (C-MSIRVTQKSYKVST) of Human keratin K8 (formerly also designated cytokeratin 8), coupled to KLH.
Specificity Specific for Keratin K8. Marker for discrimination of simple / non-stratified epithelia from those of stratified origin. Basic human keratin K8 (Mr 52 000) of all simple type and complex epithelia.
Purification Serum
Alternative Name Cytokeratin 8
Background Cytokeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.
Alternate names: CK8, CYK8, Cytokeratin endo A, Cytokeratin-8, K8, KRT8, Keratin, Keratin-8, type II cytoskeletal 8
Gene ID 3856
NCBI Accession NP_002264
UniProt P05787
Research Area Cancer, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Immunoblotting: 1: 3000, ECL method. Immunohistochemistry on frozen sections: 1: 200. Immunohistochemistry on paraffin sections: 1: 100, 1h at RT, after microwave treatment ortrypsin. Immunohistochemistry on cytological material. Positive Control: Human intestinal epitheliaOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09% Sodium Azide 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use. Shelf life one year from despatch.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for up to one month. For extended storage, mix with an equal volume of Glycerol, aliquots contents and freeze at -20°C or below.
Background publications Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

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