Keratin 13 (KRT13) antibody

Details for Product No. ABIN126069
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Antigen
Synonyms CK13, K13, Krt1-13, Krt-1.13, Ka13, ck13, k13, krt13
Reactivity
Human, Mouse (Murine)
(96), (25), (23), (16), (12), (3), (3), (2), (1), (1), (1)
Host
Guinea Pig
(55), (40), (7), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(76), (43), (26), (22), (22), (20), (10), (9), (7), (4), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN126069
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide (TTTSSASVTTTSNA-C) of Human keratin K13 (formerly also designated cytokeratin 13), coupled to KLH.
Specificity This antibody recognizes Acidic Human keratin K13 (Mr 55 000). Excellent marker to discriminate non-cornified squamous epithelia (esophagus, vagina, gingival) from those of different origin. Negative on foot sole, scalp. Tumors Specifically Detected: Several squamous cell carcinomas, e.g. cervix carcinoma, transitional cell carcinoma of the bladder, craniopharyngioma. Species Reactivity: Tested: Human, Mouse.
Purification Serum
Alternative Name Cytokeratin 13
Background Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.
Alternate names: CK-13, CK13, K13, KRT-13, KRT13, Keratin type I cytoskeletal 13, Keratin-13
Gene ID 3860
NCBI Accession NP_002265.2
UniProt P13646
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Immunoblotting: 1: 3000, ECL method. Immunohistochemistry on frozen sections: 1: 200. Immunohistochemistry on paraffin sections: 1: 100, 1h at RT, after microwave treatment. Immunohistochemistry on cytological material. Positive Control: Squamous epithelium of esophagus, gingival, palate, vagina (staining allof the suprabasal layers). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09% Sodium Azide 0.5% BSA
Preservative Sodium azide
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C Prior to and following reconstitution . DO NOT FREEZE!
Expiry Date 12 months
Background publications Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Hosts (55), (40), (7), (2)
Reactivities (96), (25), (23), (16), (12), (3), (3), (2), (1), (1), (1)
Applications (76), (43), (26), (22), (22), (20), (10), (9), (7), (4), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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