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Keratin 15 (KRT15) antibody

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Synonyms xlk2, CK15, K15, K1CO, AI528832, Krt1-15, Ka15, wu:fa91c06, wu:fa95d04, zgc:55334
Human, Mouse (Murine)
(94), (34), (31), (8), (2), (1), (1)
Guinea Pig
(57), (35), (7)
(3), (2), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(70), (43), (34), (27), (23), (11), (10), (9), (4), (3), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mL
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Immunogen Synthetic peptide of Human Keratin K15 (formerly also designated cytokeratin 15), coupled to KLH.
Specificity MW 50,000 (pI 4.9) intermediate filament polypeptide, keratin K15, detected by Immunohistochemistry in basal cells of stratified epithelia (including epidermis, tongue, esophagus, exocervix) and complex stratified epithelia (e.g. bronchial epithelium), in luminal epithelia of mammary, salivary and sweat gland. In the hair follicle, staining was restricted to the basal cell layer of the outer root sheath. Completely non-reactive were cells of liver, colon.
Purification Serum
Alternative Name Cytokeratin 15 (KRT15 Antibody Abstract)
Background Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.Synonyms: CK-15, Cytokeratin-15, K15, KRT15, KRTB, Keratin, Keratin 15, Keratin-15, Type I Cytoskeletal 15
Gene ID 3866
NCBI Accession NP_002266
UniProt P19012
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Immunofluorescence Microscopy on Frozen Sections. Immunohistochemistry on Paraffin Sections (after microwave treatment or Trypsin). Working Dilution: 1/100-1/200 for Immunohistochemistry. Incubation Time: 1h at RT. Positive Control: Sweat glands of human skin (e. g. foot sole).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for up to one month or at -20 °C for longer.
Background publications Jih, Lyle, Elenitsas et al.: "Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells." in: Journal of cutaneous pathology, Vol. 26, Issue 3, pp. 113-8, 1999 (PubMed).

Leube, Bader, Bosch et al.: "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15." in: The Journal of cell biology, Vol. 106, Issue 4, pp. 1249-61, 1988 (PubMed).

Catalog No. ABIN126070
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