Keratin 81 (KRT81) antibody

Details for Product No. ABIN126083
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Antigen
Synonyms KRT81, KRTHB5, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, AA589625, Krt2-19
Reactivity
Human, Mouse (Murine)
(24), (3), (3)
Host
Guinea Pig
(12), (11), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(24), (19), (13), (11), (8), (4), (4), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN126083
500.50 $
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Immunogen Synthetic peptide of Human basic hair (trichocytic) keratin K81 (formerly also designated keratin hHb1, C-GISSLGVGSCGSS), coupled to KLH
Specificity The antiserum stains specifically Human hair Keratin K81 present in the hair cortex and hair cuticle and tumors derived therefrom.
Purification Serum
Alternative Name Keratin-81 (KRT81)
Background KRT81 (Keratin 81) is a type II hair keratin. It is a basic protein which heterodimerizes with type I keratins to form hair and nails. It is found primarily in the hair cortex. Mutations in KRT81 have been observed in patients with, monilethrix, a rare dominant hair disease characterized by beaded or moniliform hair that results from the periodic thinning of the hair shaft and shows a high propensity to excess weathering and fracturing.Synonyms: 1, K2.9, K81, KRT81, KRTHB1, Keratin, Keratin 81, Keratin hair basic 1, Keratin-81, Keratin81, MLN 137, MLN137, Type II hair keratin Hb1, basic, ghHKb1, ghHb1, hair, type II cuticular Hb1
Gene ID 3887
NCBI Accession NP_002272
UniProt Q14533
Application Notes Immunofluorescence microscopy. Immunoblotting: 1 : 2,000, ECL method. Immunohistochemistry on frozen and paraffin (after trypsin and microwave pretreatment)sections: 1 : 200, 1h at RT.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C or (in aliquots) at -20 °C for longer.
Background publications Langbein, Rogers, Winter et al.: "The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35123-32, 2001 (PubMed).

Langbein, Spring, Rogers et al.: "Hair keratins and hair follicle-specific epithelial keratins." in: Methods in cell biology, Vol. 78, pp. 413-51, 2005 (PubMed).

General Langbein, Schweizer: "Keratins of the human hair follicle." in: International review of cytology, Vol. 243, pp. 1-78, 2005 (PubMed).

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