Calicin (CCIN) antibody

Antigen: Calicin (CCIN)

Synonyms: CCIN, MGC133688, Ccin, MGC94933, 4933417A14Rik

Clonality: Polyclonal

Host: Guinea Pig

Reactivity: Cow (Bovine), Human

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)

Catalog no.: ABIN126100

Additional Information

Characteristics: Synonyms: CCIN

Alternative name: Calicin

Swiss-Prot: Q28068

Immunogen: Synthetic N-terminal domain (aa 1-24) of bovine calicin, coupled to KLH.

Format: Serum

Description: Calicin is a basic protein of the sperm head cytoskeleton, necessary for normalmorphology during sperm differentiation. This protein contains kelch repeats and aBTB/POZ domain and is intronless.

Specificity: Sperm head calyx protein calicin (mw 66,889, IEP 8. 1, 588 amino acids), testis specificcytoskeletal protein Homologue to kelch protein of the ring canal structure of Drosophilaovaries. Useful to study spermiogenetic differentiation. Calicin is absent from pathologicforms like roundheaded or other post-acrosomal sheath defect sperm malformations. Species: Human, Bovine, Rabbit, Rat, Mouse. Others not tested.

Application Details

Application Notes: Immunohistochemistry on frozen: 1/100, 1h at RT. Western blot: 1/2000 (ECL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Storage: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Research Area: Reproduction, Cytoskeleton, Microfilaments

Restrictions: For Research Use only

Publications

Publications: von Buelow, Heid, Hess et al.: "Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton." in: Experimental cell research, Vol. 219, Issue 2, pp. 407-13, 1995 (PubMed).