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Synaptophysin antibody (SYP)

Details for Product anti-SYP Antibody No. ABIN126704, Supplier: Login to see New
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Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(266), (88), (68), (29), (8), (6), (4), (3), (3), (3), (1), (1), (1), (1)
(190), (132), (6), (1)
Clonality (Clone)
Monoclonal ()
This Synaptophysin antibody is un-conjugated
(8), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(240), (123), (95), (59), (43), (35), (18), (17), (13), (4), (4), (4), (4), (3), (1), (1)
Pubmed 8 references available
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Quantity 1 mL
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Immunogen Synaptophysin (presynaptic vesicles).
Clone SY38
Isotype IgG1
Specificity Reacts with Rat PC-12 cultured cell line. Polypeptide reacting: Mr 38 000 transmembrane glycoprotein of presynaptic vesicles. SY 38 represents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid.
Purification Ascites
Alternative Name Synaptophysin / SYP (SYP Antibody Abstract)
Background Synaptopodin, a prolin-rich actin-binding protein with 2 binding sites for actin, represents a new class of actin-binding proteins which has first been localized in podocytes and a subset of telencephalic postsynaptic densities. In human tissue synaptopodin has a molecular weight of 73.7 kD and pI of 9.38 (calculated from sequence data), in mouse the corresponding data are 74 kD, pI 9.27. In SDS-PAGE the antigen appears as 100 kD polypeptide in brain and 110 kD polypeptide in kidney (the difference might be attributed to posttranslational modifications).Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker
Gene ID 6855
NCBI Accession NP_003170
UniProt P08247
Application Notes Immunoblotting. Immunocytochemistry. Immunohistochemistry on Frozen SectionsImmunohistochemistry on Paraffin Embedded Tissue (in No case proteolytic treatment). Working Dilutions: 1/10 for Immunohistochemistry. Incubation Time: 1h at RT, extended for paraffin sections (overnight at 2-8 °C).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Product cited in: Khan, Tsigani, Rashid et al.: "Circulating tumor cells and EpCAM expression in neuroendocrine tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 2, pp. 337-45, 2011 (PubMed).

Background publications Leube: "The topogenic fate of the polytopic transmembrane proteins, synaptophysin and connexin, is determined by their membrane-spanning domains." in: Journal of cell science, Vol. 108 ( Pt 3), pp. 883-94, 1995 (PubMed).

Wiedenmann, Franke: "Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles." in: Cell, Vol. 41, Issue 3, pp. 1017-28, 1985 (PubMed).

Gould: "Synaptophysin. A new and promising pan-neuroendocrine marker." in: Archives of pathology & laboratory medicine, Vol. 111, Issue 9, pp. 791-4, 1987 (PubMed).

Gould, Wiedenmann, Lee et al.: "Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry." in: The American journal of pathology, Vol. 126, Issue 2, pp. 243-57, 1987 (PubMed).

Gould, Lee, Wiedenmann et al.: "Synaptophysin: a novel marker for neurons, certain neuroendocrine cells, and their neoplasms." in: Human pathology, Vol. 17, Issue 10, pp. 979-83, 1986 (PubMed).

Wiedenmann, Franke, Kuhn et al.: "Synaptophysin: a marker protein for neuroendocrine cells and neoplasms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 10, pp. 3500-4, 1986 (PubMed).

Bennett, Calakos, Kreiner et al.: "Synaptic vesicle membrane proteins interact to form a multimeric complex." in: The Journal of cell biology, Vol. 116, Issue 3, pp. 761-75, 1992 (PubMed).

Catalog No. ABIN126704

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