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Synaptophysin antibody (SYP) FITC

Details for Product anti-SYP Antibody No. ABIN126706, Supplier: Login to see New
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Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(266), (88), (68), (29), (8), (6), (4), (3), (3), (3), (1), (1), (1), (1)
(190), (132), (6), (1)
Clonality (Clone)
Monoclonal ()
This Synaptophysin antibody is conjugated to FITC
(8), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
(240), (123), (95), (59), (43), (35), (18), (17), (13), (4), (4), (4), (4), (3), (1), (1)
Pubmed 6 references available
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Quantity 0.25 mL
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Immunogen Synaptophysin from presynaptic vesicles, prepared from Bovine brain
Clone SY38
Isotype IgG1
Specificity SY38 represents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid. Polypeptide Reacting: Mr 38 000 transmembrane glycoprotein of presynaptic vesicles. Tested Reactivities on Cultured cell lines: Rat PC-12 cell line.
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine, Rat and Mouse.
Purification Affinity Chromatography on Protein A
Alternative Name Synaptophysin / SYP (SYP Antibody Abstract)
Background Synaptophysin is a glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non chromaffin paragangliomas.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker
Gene ID 6855
NCBI Accession NP_003170
UniProt P08247
Application Notes Immunofluorescence Microscopy. Suitable for Frozen tissue and Cytological Material. In no case protease pre-treatment. Dilute at least 1/10 with PBS, pH 7.4 for Immunofluorescence Microscopy. Incubation time: 1 h at RT.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kelly, Delclos, Morice et al.: "High-dose-rate endobronchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M. D. Anderson cancer center experience." in: International journal of radiation oncology, biology, physics, Vol. 48, Issue 3, pp. 697-702, 2000 (PubMed).

Wiedenmann, Franke: "Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles." in: Cell, Vol. 41, Issue 3, pp. 1017-28, 1985 (PubMed).

Gould: "Synaptophysin. A new and promising pan-neuroendocrine marker." in: Archives of pathology & laboratory medicine, Vol. 111, Issue 9, pp. 791-4, 1987 (PubMed).

Gould, Wiedenmann, Lee et al.: "Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry." in: The American journal of pathology, Vol. 126, Issue 2, pp. 243-57, 1987 (PubMed).

Gould, Lee, Wiedenmann et al.: "Synaptophysin: a novel marker for neurons, certain neuroendocrine cells, and their neoplasms." in: Human pathology, Vol. 17, Issue 10, pp. 979-83, 1986 (PubMed).

Wiedenmann, Franke, Kuhn et al.: "Synaptophysin: a marker protein for neuroendocrine cells and neoplasms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 10, pp. 3500-4, 1986 (PubMed).

Catalog No. ABIN126706

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