anti-LRP5 antibody (Low Density Lipoprotein Receptor-Related Protein 5)

Details for Product anti-LRP5 Antibody No. ABIN126948
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Human, Mouse (Murine)
(94), (49), (32), (1), (1), (1), (1), (1)
(80), (16), (12), (2)
Clonality (Clone)
Monoclonal ()
This LRP5 antibody is un-conjugated
(8), (8), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(71), (54), (29), (20), (14), (6), (5), (4), (3), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States ( )
Availability Please contact our customer support.
Immunogen Synthetic peptide (DTGTDRIEVTR) derived from Human LRP-6. These residues arecompletely conserved between Human and Mouse and between LRP-5 and LRP-6.
Clone 1A12
Isotype IgG2b
Characteristics Synonyms: LRP5, LRP7, Low-density lipoprotein receptor-related protein 5, LRP6, Low-densitylipoprotein receptor-related protein 6
Purification Affinity Chromatography.
Alternative Name LRP5 + LRP6 (LRP5 Antibody Abstract)
Background LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.Synonyms: LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6
Research Area Stem Cells, Wnt, Extracellular Matrix, Wnt Signaling
Pathways WNT Signaling
Application Notes Western blot: 1-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 10 mM Tris-glycine ( pH 7.0) containing 0.15 M NaCl, 25 % Glycerol, 0.5 % BSA, and 0.01 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C/-80 °C
Storage Comment Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Li, Mao, Sun et al.: "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 5977-81, 2002 (PubMed).

Catalog No. ABIN126948
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