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Details for Product No. ABIN126948

Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) antibody

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Synonyms HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2, mKIAA4142, Xlrp5, bmnd1, evr1, evr4, hbm, lr3, lrp5-A, lrp7, oppg, ops, opta1, vbch2, LRP5, LRP6
»Alternatives Human, Mouse (Murine)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN126948
Quantity 0.1 mg
489.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide (DTGTDRIEVTR) derived from Human LRP-6. These residues arecompletely conserved between Human and Mouse and between LRP-5 and LRP-6.
Clone 1A12
Isotype IgG2b
Characteristics Synonyms: LRP5, LRP7, Low-density lipoprotein receptor-related protein 5, LRP6, Low-densitylipoprotein receptor-related protein 6
Purification Affinity Chromatography.
Alternative Name LRP5 + LRP6
Background LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, whichwere found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 wasshown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopusembryos. Mice lacking LRP-6 exhibited developmental defects that are similar to thosecaused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteinsinduce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.
Research Area Stem Cells, Wnt, Extracellular Matrix
Application Notes Western blot: 1-2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 10 mM Tris-glycine (pH 7.0) containing 0.15M NaCl, 25% Glycerol, 0.5% BSA, and 0.01% Sodium Azide
Preservative Sodium azide
Storage -20 °C/-80 °C
Storage Comment Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Li, Mao, Sun et al.: "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 5977-81, 2002 (PubMed).

Alternatives for antigen "Low Density Lipoprotein Receptor-Related Protein 5 (LRP5)", type "Antibodies"
Hosts (45), (12), (6), (1)
Reactivities (59), (38), (27), (24), (24), (12), (12)
Applications (38), (26), (20), (14), (4), (4), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (11), (4), (3), (2), (2), (2), (1), (1)