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Details for Product No. ABIN127030

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term), (active) antibody

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Antigen
Synonyms MCH2, Mch2, mCASP-6, xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6
Epitope
»Alternatives C-Term, active
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN127030
Quantity 0.1 mg
Price
511.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide surrounding amino acids mapping to the Cterminus of the large fragment of human caspase-6.
Specificity The antibody detects the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize other caspases.
Purification Affinity purified
Alternative Name Caspase-6
Background Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP- ribose) polymerase (PARP) and nuclear lamin A.
Alternate names: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
NCBI Accession NP_001217.2
UniProt P55212
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 0.5-4 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C/-80 °C
Storage Comment Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
Expiry Date 12 months
Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Antibodies"
Hosts (159), (33), (2)
Reactivities (181), (93), (82), (16), (7), (4), (2), (2), (2), (2), (2)
Applications (149), (72), (63), (40), (40), (29), (25), (20), (7), (5), (4), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (43), (28), (22), (8), (7), (6), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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