CTSL1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Blot: 0.5-4 μg/mL, Jurkat cell lysate can be used as a positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid propeptide, to generate the active two-chain form made up of 21 and 5 kDa subunits. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. The fact that Cathepsin L is also capable of degrading extracellular matrix proteins suggests that it may play a role in invation and metastasis and could be a useful prognostic indicator for cancer.Synonyms: CTSL, CTSL1, Cathepsin-L1, MEP, Major excreted protein