RGS3 antibody (AA 401-519)

Catalog No. ABIN127074

Product Details anti-RGS3 Antibody

Target: RGS3 (Regulator of G-Protein Signaling 3 (RGS3))

Binding Specificity: AA 401-519

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: This antibody detects human RGS3. Other species not tested.

Purification: Protein A chromatography

Immunogen: E. coli-expressed human RGS3 (aa 401-519)

Application Details

Application Notes: Western Blot: 1.0 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C to -70 °C.

Target Details for RGS3

Target: RGS3 (Regulator of G-Protein Signaling 3 (RGS3))

Alternative Name: RGS3 (RGS3 Products)

Synonyms: RGS3 antibody, MGC115680 antibody, C2PA antibody, RGP3 antibody, 4930506N09Rik antibody, C2PA-RGS3 antibody, C2pa antibody, PDZ-RGS3 antibody, RGS3S antibody, SRB-RGS antibody, regulator of G protein signaling 3 antibody, regulator of G-protein signaling 3 L homeolog antibody, regulator of G-protein signaling 3 antibody, RGS3 antibody, rgs3.L antibody, Rgs3 antibody

Background: RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed in many tissues and cells. The protein contains an RGS domain near the carboxy terminus that serves as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Giα and Gαq. A truncated RGS3 (RGS3T), with its N-terminal 313 residues removed, has been shown to negatively regulate acenylyl cyclase and PLC. RGS3T may be localized in the nucleus and RGS3 is found in cytoplasm. Translocation to membrane is important for the RGS proteins to interact with heterotrimeric G proteins.Synonyms: RGP3, Regulator of G-protein signaling 3

Gene ID: 5998

NCBI Accession: NP_060260

UniProt: P49796

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling